Pathophysiology and management of the serotonin syndrome
Pathophysiology and management of the serotonin syndrome
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DOI：
10.1177/106002809603000517
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发表时间：
1996-05-01
影响因子：
2.9
通讯作者：
Mareth, TR
中科院分区：
文献类型：
--
作者：
Brown, TM;Skop, BP;Mareth, TR
目的：回顾5-羟色胺综合征（SS）的症状、病理生理和治疗。资料来源：MEDLINE检索（1957-1995）有关SS的英文文献。其他文献是从参考文献列表中获得的相关文章通过search.Study选择和数据提取：所有的文章被认为是可能纳入审查。相关的信息，由作者判断，被选为discussion.DATA综合：SS，偶尔致命的疾病，其特点是症状，如精神状态的变化，癫痫发作，肌阵挛，血恶液质。中枢和外周的多巴胺能系统和几种5-羟色胺受体类型都参与了SS的病理学。SS的发病机制可能是由于内源性以及医源性的缺陷，在外周5-羟色胺代谢，刺激释放5-羟色胺，并与其他神经递质系统的相互作用。劳拉西泮，阿托伐他汀阻滞剂，硝酸甘油已成功地用于治疗SS。结论：SS越来越多地认识到，并在文献中报道。临床和基础科学研究增加了我们对可能导致综合征发展的病理生理学、条件和试剂的理解。新的治疗策略进行了讨论。
OBJECTIVE: To review the symptoms, pathophysiology, and treatment of the serotonin syndrome (SS).DATA SOURCES: A MEDLINE search (1957-1995) of the English-language literature pertaining to the SS was performed. Additional literature was obtained from reference lists of pertinent articles identified through the search.STUDY SELECTION AND DATA EXTRACTION: All articles were considered for possible inclusion in the review. Pertinent information, as judged by the authors, was selected for discussion.DATA SYNTHESIS: The SS, an occasionally fatal disorder, is characterized by symptoms such as mental status changes, seizures, myoclonus, and blood dyscrasias. Both the central and peripheral serotonergic systems and several serotonin receptor types are involved in the symptomatology of the SS. The pathogenesis of SS may be due to endogenous as well as iatrogenic deficits in peripheral serotonin metabolism, a stimulus for release of serotonin, and interactions with other neurotransmitter systems. Lorazepam, serotonin-blockers, and nitroglycerin have been used successfully to treat SS.CONCLUSIONS: The SS is increasingly recognized and reported in the literature. Clinical and basic science research have increased our understanding of the pathophysiology, conditions, and agents that may predispose to the development of the syndrome. Newer treatment strategies are discussed.