Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications.
Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications.
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DOI：
10.4172/2167-0501.1000202
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Singh, Amar B
中科院分区：
文献类型：
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作者：
Ahmad, Rizwan;Dhawan, Punita;Singh, Amar B
肿瘤干细胞(CSCs)是一类具有独特生物学特性的罕见肿瘤细胞亚群，具有自我更新、去分化、启动和维持恶性肿瘤生长的能力。研究进一步报道，CSCs是癌症复发和治疗耐药的主要因素。因此，靶向CSCs抑制肿瘤进展已成为一种有吸引力的抗癌治疗策略。最近的技术进步使人们对肿瘤发生的多步骤性质有了更多的认识，也澄清了CSC的概念并不是普遍适用的。无论如何，CSCs在胃肠道(GI)癌症中的作用已被广泛接受和赞赏，GI癌症是大多数癌症相关死亡的罪魁祸首。然而，尽管在过去的十年中，在开发识别肿瘤干细胞的标志物和评估肿瘤干细胞的致瘤功能方面取得了巨大的进步，但它仍然是一个积极的研究领域。在当前的文章中，我们回顾了与肿瘤干细胞在胃肠道肿瘤中的作用和鉴定有关的研究结果，并讨论了调控肿瘤干细胞群体发展和耐药性的关键途径，以及利用肿瘤样培养来测试肿瘤干细胞靶向癌症治疗的新方法。
The cancer stem cells (CSCs) are biologically distinct subset of rare cancer cells with inherent ability of self-renewal, de-differentiation, and capacity to initiate and maintain malignant tumor growth. Studies have further reported that CSCs prime cancer recurrence and therapy resistance. Therefore, targeting CSCs to inhibit cancer progression has become an attractive anti-cancer therapeutical strategy. Recent technical advances have provided a greater appreciation of the multistep nature of the oncogenesis and also clarified that CSC concept is not universally applicable. Irrespective, the role of the CSCs in gastrointestinal (GI) cancers, responsible for the most cancer-associated death, has been widely accepted and appreciated. However, despite the tremendous progress made in the last decade in developing markers to identify CSCs, and assays to assess tumorigenic function of CSCs, it remains an area of active investigation. In current article, we review findings related to the role and identification of CSCs in GI-cancers and discuss the crucial pathways involved in regulating CSCs populations' development and drug resistance, and use of the tumoroid culture to test novel CSCs-targeted cancer therapies.