Leukotriene C4 induces mesenteric hypoperfusion and intestinal intramural acidosis in pigs.
Leukotriene C4 induces mesenteric hypoperfusion and intestinal intramural acidosis in pigs.
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白三烯 C4 会导致猪肠系膜灌注不足和肠壁内酸中毒。
DOI：
10.1016/0022-4804(91)90195-r
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Fink,MP
中科院分区：
文献类型：
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作者：
Cohn,SM;Kruithoff,KL;Rothschild,HR;Wang,HL;Antonsson,JB;Heard,SO;Fink,MP
我们研究了静脉输注分级剂量的真实白三烯（LT）C4对戊巴比妥麻醉的未成熟猪的几个生理变量的影响。使用超声流量探头测量肠系膜血流量（Q_（max）），并通过张力计估计回肠粘膜内氢离子浓度（[H+]I）。研究了三组。组I中的猪（n= 6）从att= 0 min开始以增加的剂量输注（0.03-1.0 μg/kg-min）的LTC 4，每次给药10分钟。组II（n= 6）中的猪如上所述输注LTC 4，但用特异性硫肽LT受体拮抗剂预处理和后处理，LY 203647（30 mg/kg推注，然后10 mg/kg-h），开始att=-20 min。组III（n= 4）中的猪仅接受生理盐水（5 ml/kg-h）。输注LTC 4可显著降低Q-肌和肠系膜氧摄取，显著增加回肠[H+]I。LY 203647阻止了这些变化。这些数据支持硫肽LT能够引起肠系膜缺血并且这种现象可以被LY 203647阻断的观点。
We examined the effect of intravenous infusion of graded doses of authentic leukotriene (LT) C4on several physiological variables in pentobarbital-anesthetized immature swine. Mesenteric blood flow (Q̊sma) was measured using an ultrasonic flow probe and ileal intramucosal hydrogen ion concentration ([H+]I) was estimated tonometrically. Three groups were studied. Pigs in Group I (n= 6) were infused beginning att= 0 min with increasing doses (0.03–1.0 μg/kg-min) of LTC4, each dose being administered for 10 min. Pigs in Group II (n= 6) were infused with LTC4as above, but were pre- and post-treated with a specific sulfidopeptide LT receptor antagonist, LY203647 (30 mg/kg bolus and then 10 mg/kg-hr) beginning att= −20 min. Pigs in Group III (n= 4) received only normal saline (5 ml/kg-h). Infusing LTC4significantly decreased Q̊sma and mesenteric oxygen uptake and significantly increased ileal [H+]I. These changes were prevented by LY203647. These data support the idea that sulfidopeptide LT are capable of causing mesenteric ischemia and that this phenomenon can be blocked by LY203647.