Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women
Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women
复制标题
DOI：
10.1046/j.1532-5415.2003.51558.x
复制
发表时间：
2003-12-01
影响因子：
6.3
通讯作者：
Cummings, SR
中科院分区：
文献类型：
--
作者：
Ensrud, KE;Ewing, SK;Cummings, SR
目的：检验无意减重比有意减重更能增加骨质丢失和髋部骨折风险的假设。设计：前瞻性队列研究。背景：美国境内的四个社区。参与者：6,785名老年白人女性，测量体重变化并评估减肥意向。测量：基线和第四次检查之间的体重变化(两次检查之间的平均5.7年)和减肥意向评估。体重下降定义为较基线体重下降5%或以上，稳定体重定义为较基线体重变化小于5%，体重增加定义为较基线体重增加5%或以上。用双能X射线骨密度仪测量第四次和第六次检查之间的髋部骨密度变化率(平均检查间隔4.4年)。结果：调整后的髋部骨密度下降的平均速度在体重增加的女性中为-0.52%，在体重稳定的女性中为-0.68%，在体重减轻的女性中为-0.92%(趋势P值
Objectives: To test the hypothesis that unintentional weight loss increases the rate of bone loss and risk of hip fracture more than intentional weight loss.Design: Prospective cohort study.Setting: Four communities within the United States.Participants: Six thousand seven hundred eighty-five elderly white women with measurement of weight change and assessment of intention to lose weight.Measurements: Weight change between baseline and fourth examinations (average 5.7 years between examinations) and assessment of intention to lose weight. Weight loss was defined as a decrease of 5% or more from baseline weight, stable weight was defined as less than a 5% change from baseline weight, and weight gain was defined as an increase of 5% or more from baseline weight. Rate of change in bone mineral density at the hip between fourth and sixth examinations (average 4.4 years between examinations) was measured using dual-energy x-ray absorptiometry. Incident hip fractures occurring after the fourth examination until June 1, 2001 (average follow-up 6.6 years) was confirmed using radiographic reports.Results: The adjusted average rate of decline in total hipbone density steadily increased from -0.52% per year in women with weight gain to -0.68% per year in women with stable weight to -0.92% per year in women with weight loss (P-value for trend