Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.
Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.
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新型的脂质介质促进了急性炎症的分辨率：阿司匹林和他汀类药物的影响。
DOI：
10.1161/circresaha.110.223883
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发表时间：
2010-11-12
影响因子：
20.1
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Spite M;Serhan CN
急性炎症的消退是允许发炎组织恢复稳态的过程。分辨率被认为是一个被动的过程，一个概念，现在推翻了新的证据表明，决议是积极精心策划的独特的细胞事件和内源性化学介质。其中，脂质介质，如脂氧素，resolvins，protectins和新发现的maresins，已成为一个新的属的有效的和立体选择性的球员，反调节过度急性炎症和刺激分子和细胞的事件，定义解决。鉴于不受控制的慢性炎症与许多心血管病理学相关，对控制及时消退的内源性途径和介质的认识可以为靶向刺激局部炎症消退以及纠正慢性炎症对心血管疾病的影响的治疗方法开辟新的领域。在这里，我们概述和更新的生物合成和行动的前解决脂质介质，突出其不同的保护作用，血管系统和阿司匹林和他汀类药物治疗的关系。
The resolution of acute inflammation is a process that allows for inflamed tissues to return to homeostasis. Resolution was held to be a passive process, a concept now overturned with new evidence demonstrating that resolution is actively orchestrated by distinct cellular events and endogenous chemical mediators. Among these, lipid mediators, such as the lipoxins, resolvins, protectins and newly identified maresins, have emerged as a novel genus of potent and stereoselective players that counter-regulate excessive acute inflammation and stimulate molecular and cellular events that define resolution. Given that uncontrolled, chronic inflammation is associated with many cardiovascular pathologies, an appreciation of the endogenous pathways and mediators that control timely resolution can open new terrain for therapeutic approaches targeted at stimulating resolution of local inflammation, as well as correcting the impact of chronic inflammation in cardiovascular disorders. Here, we overview and update the biosynthesis and actions of pro-resolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies.