Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat
Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat
复制标题
DOI：
10.1006/bbrc.1998.8303
复制
发表时间：
1998-03-27
影响因子：
3.1
通讯作者：
Belury, MA
中科院分区：
文献类型：
--
作者：
Houseknecht, KL;Vanden Heuvel, JP;Belury, MA
共轭亚油酸（CLA）是一种天然存在的脂肪酸，具有抗癌和抗动脉粥样硬化的特性，CLA激活肝脏中的PPAR α，并且与PPAR γ的配体噻唑烷二酮（thiazolidinediones）具有功能相似性，其是有效的胰岛素增敏剂。我们提供了CLA能够使糖尿病前期ZDF大鼠的葡萄糖耐量受损正常化并改善高胰岛素血症的第一个证据。此外，与对照相比，饮食CLA增加了脂肪ZDF大鼠脂肪组织中aP 2 mRNA的稳态水平，这与PPAR γ的活化一致。CLA的胰岛素增敏作用，至少部分地，由于CLA水平的增加在用PPAR γ和PPRE X 3-共转染的CV-1细胞中诱导了剂量依赖性的PPAR γ反式激活，通过荧光素酶报告基因构建，CLA对葡萄糖耐量和葡萄糖稳态的影响表明，膳食CLA可能被证明是预防和治疗NIDDM的重要疗法。(C)北京：科学出版社.
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid which has anti-carcinogenic and anti-atherogenic properties, CLA activates PPAR alpha in liver, and shares functional similarities to ligands of PPAR gamma, the thiazolidinediones, which are potent insulin sensitizers, We provide the first evidence that CLA is able to normalize impaired glucose tolerance and improve hyperinsulinemia in the pre-diabetic ZDF rat, Additionally, dietary CLA increased steady state levels of aP2 mRNA in adipose tissue of fatty ZDF rats compared to controls, consistent with activation of PPAR gamma, The insulin sensitizing effects of CLA are due, at least in part, to activation of PPAR gamma since increasing levels of CLA induced a dose-dependent transactivation of PPAR gamma in CV-1 cells cotransfected with PPAR gamma and PPRE X 3-luciferase reporter construct, CLA effects on glucose tolerance and glucose homeostasis indicate that dietary CLA may prove to be an important therapy for the prevention and treatment of NIDDM. (C) 1998 Academic Press.