Neural dynamics of saccadic suppression.
Neural dynamics of saccadic suppression.
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DOI：
10.1523/jneurosci.2908-09.2009
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发表时间：
2009-10-07
期刊：
影响因子：
--
通讯作者：
Krekelberg B
中科院分区：
文献类型：
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作者：
Bremmer F;Kubischik M;Hoffmann KP;Krekelberg B
我们做快速，弹道眼运动称为扫视更经常比我们的心跳。即使每一次扫视都会引起我们视网膜上环境图像的大幅度移动，我们也从未感知到这种运动。感知稳定性的这一方面通常被称为扫视抑制：扫视时视觉灵敏度的降低。在这里，我们研究了这种感知现象的神经基础与细胞外记录清醒，表现猴子在中颞（MT），内侧上级颞（MST），腹侧顶内（VIP），和外侧顶内（LIP）地区。我们发现，在这些区域中的每一个区域中，对视觉刺激的神经反应都会在眼球运动周围发生变化。在这些区域中的每一个区域中，近囊响应变化都是质的不同的，这表明它们不是由共同输入区域的变化引起的。重要的是，我们的数据表明，在背流的抑制开始之前，眼睛的运动。这清楚地表明，这种抑制不仅仅是眼球运动过程中视觉输入变化的结果，而是必须涉及一个在扫视之前积极调节神经活动的过程。
We make fast, ballistic eye movements called saccades more often than our heart beats. Even though every saccade causes a large movement of the image of the environment on our retina, we never perceive this motion. This aspect of perceptual stability is often referred to as saccadic suppression: a reduction of visual sensitivity around the time of saccades. Here, we investigated the neural basis of this perceptual phenomenon with extracellular recordings from awake, behaving monkeys in the middle temporal (MT), medial superior temporal (MST), ventral intraparietal (VIP), and lateral intraparietal (LIP) areas. We found that in each of these areas the neural response to a visual stimulus changes around an eye movement. The perisaccadic response changes are qualitatively different in each of these areas, suggesting that they do not arise from a change in a common input area. Importantly, our data show that the suppression in the dorsal stream starts well before the eye movement. This clearly shows that the suppression is not just a consequence of the changes in visual input during the eye movement, but rather must involve a process that actively modulates neural activity just before a saccade.