Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer
Loss of PCDH9 is associated with the differentiation of tumor cells and metastasis and predicts poor survival in gastric cancer
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DOI：
10.1007/s10585-015-9712-7
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发表时间：
2015-06-01
影响因子：
4
通讯作者：
Yu, Guanzhen
中科院分区：
文献类型：
--
作者：
Chen, Ying;Xiang, Honggang;Yu, Guanzhen
基因芯片研究显示PCDH 9 mRNA在胃癌淋巴结转移中的表达水平较原发灶明显下调。应用组织芯片技术检测1072例胃癌组织中PCDH 9蛋白的表达，并分析其与临床病理的关系。在一个175例胃癌的小队列中进一步评估其预后价值。PCDH 9在胃癌的发生、发展过程中表达下调。PCDH 9在正常组织、原发肿瘤、淋巴结和肝转移组织中的总表达率分别为100%（1072/1072）、48.0%（515/1072）、20.1%（34/169）和5.6%（1/18）。PCDH 9蛋白阳性表达与肿瘤大小、分化程度、浸润深度、淋巴结转移及疾病进展密切相关。考克斯比例风险模型显示PCDH 9是胃癌的独立预后因素。因此，PCDH 9的表达下降是常见的人类胃癌转移和PCDH 9的表达是一个独立的预后因素，这表明PCDH 9可能是一个有前途的生物标志物，这种恶性肿瘤。
Microarray studies revealed down-regulation of PCDH9 mRNA level in lymph node metastasis of gastric cancer compared with the primary tumors. The expression of PCDH9 protein and its clinicopathological relevance were assessed on tissue microarrays of 1072 cases of gastric cancer. Its prognostic value was further evaluated on a small cohort of 175 gastric cancers. PCDH9 was down-regulated during the development and progression of gastric cancer. The overall rates of PCDH9 expression in normal, primary tumor, nodal and hepatic metastatic tissues were 100 % (1072/1072), 48.0 % (515/1072), 20.1 % (34/169), and 5.6 % (1/18), respectively. Positive staining of PCDH9 protein was significantly reversely correlated with tumor size, tumor differentiation, tumor invasion, lymph node metastasis, and disease progression. The Cox proportional hazards model revealed that the PCDH9 was an independent prognostic factor for gastric cancer. Therefore, decreased expression of PCDH9 is frequent in human gastric cancer metastasis and PCDH9 expression is an independent prognostic factor, suggesting that PCDH9 could be a promising biomarker of this malignancy.