Three new coumarin glycosides from the stems of Hydrangea paniculata
Three new coumarin glycosides from the stems of Hydrangea paniculata
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绣球花茎中的三种新香豆素苷
DOI：
10.1080/10286020.2017.1305958
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发表时间：
2017-01-01
影响因子：
1.7
通讯作者：
Zhang, Dong-Ming
中科院分区：
文献类型：
--
作者：
Ma, Jie;Li, Chuang-Jun;Zhang, Dong-Ming
从圆锥绣球（Hydrangea paniculata Sieb.）的茎中分离得到三个新的香豆素苷类化合物（1-3）和三个已知化合物（4-6）。根据光谱数据和化学证据鉴定了它们的结构。此外，筛选了化合物1-3对血清剥夺诱导的PC 12细胞损伤的神经保护作用、对HL-7702细胞中DL-半乳糖胺诱导的毒性的肝保护活性以及它们抑制LPS诱导的鼠小胶质细胞BV 2细胞系中一氧化氮产生的能力，但它们是无活性的。
Abstract Three new coumarin glycosides (1-3), together with three known compounds (4-6), have been obtained from the stems of Hydrangea paniculata Sieb. Their structures were elucidated based on spectroscopic data and chemical evidence. In addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced PC12 cell damage, hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, but they were inactive.