A constitutive model for developing blood clots with various compositions and their nonlinear viscoelastic behavior.
A constitutive model for developing blood clots with various compositions and their nonlinear viscoelastic behavior.
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DOI：
10.1007/s10237-015-0686-9
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发表时间：
2016-04
影响因子：
3.5
通讯作者：
Peters GW
中科院分区：
文献类型：
--
作者：
van Kempen TH;Donders WP;van de Vosse FN;Peters GW
机械特性在很大程度上决定了血块的功能。这些特性取决于凝块的成分，并且与许多疾病有关。然而，涉及的各种组件及其复杂的相互作用使得现阶段很难完全理解和预测作为组件函数的属性。因此，在本研究中，开发了一个本构模型来描述具有不同成分的血凝块的粘弹性行为。迄今为止，由全血、富含血小板的血浆和贫血小板血浆形成凝块，以分别研究红细胞、血小板和纤维蛋白的影响。进行流变学实验以探究凝块形成过程中的机械行为。使用大幅度振荡剪切变形来表征成熟凝块的非线性粘弹性行为。该模型基于广义麦克斯韦模型，该模型通过使模量和粘度成为时间以及过去和当前变形的函数来准确描述不同流变实验的结果。使用具有不同参数值的相同模型可以描述具有不同成分的凝块。应用敏感性分析来研究参数变化对模型输出的影响。相对简单性和灵活性使该模型适合对血凝块和其他表现出类似行为的材料进行数值模拟。本文的在线版本 (doi:10.1007/s10237-015-0686-9) 包含补充材料，可供授权用户使用。
The mechanical properties determine to a large extent the functioning of a blood clot. These properties depend on the composition of the clot and have been related to many diseases. However, the various involved components and their complex interactions make it difficult at this stage to fully understand and predict properties as a function of the components. Therefore, in this study, a constitutive model is developed that describes the viscoelastic behavior of blood clots with various compositions. Hereto, clots are formed from whole blood, platelet-rich plasma and platelet-poor plasma to study the influence of red blood cells, platelets and fibrin, respectively. Rheological experiments are performed to probe the mechanical behavior of the clots during their formation. The nonlinear viscoelastic behavior of the mature clots is characterized using a large amplitude oscillatory shear deformation. The model is based on a generalized Maxwell model that accurately describes the results for the different rheological experiments by making the moduli and viscosities a function of time and the past and current deformation. Using the same model with different parameter values enables a description of clots with different compositions. A sensitivity analysis is applied to study the influence of parameter variations on the model output. The relative simplicity and flexibility make the model suitable for numerical simulations of blood clots and other materials showing similar behavior. The online version of this article (doi:10.1007/s10237-015-0686-9) contains supplementary material, which is available to authorized users.