Human and murine obliterative bronchiolitis in transplant.
Human and murine obliterative bronchiolitis in transplant.
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DOI：
10.1513/pats.200605-107jg
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
McDyer, John F
中科院分区：
文献类型：
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作者：
McDyer, John F
闭塞性细支气管炎是限制肺移植长期成功的一种毁灭性疾病。它的高患病率和对当前治疗措施的总体不良反应需要进一步研究以阐明致病机制。为了实现这一目标，动物模型在研究闭塞性细支气管炎的机制中发挥了作用，例如小鼠异位气管同种异体移植模型。这篇综述比较了气管同种异体移植模型与人闭塞性细支气管炎病理学，并强调了使用该模型描述的气道排斥反应的重要机制。尽管存在一定的局限性，但在该模型以及其他动物模型中进行概念验证研究可以为针对移植后闭塞性细支气管炎发病机制的遗传和细胞转化人类研究提供基础。为了应对这些挑战，我们呼吁建立美国国立卫生研究院支持的肺移植网络，以更好地协调闭塞性细支气管炎发病机制和治疗方面的转化研究工作，并推进肺移植领域。
Obliterative bronchiolitis is a devastating illness that limits the long-term success of lung transplantation. Its high prevalence and overall poor response to current therapeutic measures demands further research to elucidate pathogenic mechanisms. Toward this goal, there is a role for animal models to study the mechanisms of obliterative bronchiolitis, such as the murine heterotopic tracheal allograft model. This review compares the tracheal allograft model to human obliterative bronchiolitis pathology and highlights the important mechanisms of airway rejection described using this model. Although certain limitations exist, the pursuit of proof-of-concept studies in this model, as well as other animal models, can provide the basis for genetic and cellular translational human studies directed toward post-transplant obliterative bronchiolitis pathogenesis. To meet these challenges, we call for the establishment of a National Institutes of Health-supported Lung Transplant Network to better orchestrate translational research efforts in obliterative bronchiolitis pathogenesis and treatment, and to advance the field of lung transplantation.