Congenital and postnatally acquired cytomegalovirus infections: long-term follow-up.
Congenital and postnatally acquired cytomegalovirus infections: long-term follow-up.
复制标题
先天性和产后获得性巨细胞病毒感染：长期随访。
DOI：
10.1016/s0022-3476(84)80942-7
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Gold,E
中科院分区：
文献类型：
--
作者：
Kumar,ML;Nankervis,GA;Jacobs,IB;Ernhart,CB;Glasson,CE;McMillan,PM;Gold,E
为了确定隐性先天性巨细胞病毒感染儿童的长期结局，对出生后观察到的先天性感染儿童进行了评估。还对出生后早期获得CMV感染的儿童进行了评估。对48名患者进行了认知、行为、神经、听力、言语和语言评估，其中包括17名先天性感染儿童、10名出生后感染儿童和21名未感染对照组。三组儿童的平均智商没有显著差异。行为，神经，言语和语言检查同样未能区分三组之间的差异。听力异常存在于四个先天性感染的儿童，包括一个孩子有严重的单侧感觉神经性损失，在没有孩子听力损失功能显着。在出生后感染的儿童中未发现听力异常。虽然不明显的CMV感染可导致听力学后遗症，但这些学龄儿童持续缺乏认知、行为和神经学后遗症，再次强调需要将注意力集中在预防原发性母体CMV感染上，以避免宫内CMV感染的潜在破坏性影响。
To determine long-term outcome of children with inapparent congenital cytomegalovirus infection, an assessment of congenitally infected children observed since birth was undertaken. Children with early postnatal acquisition of CMV infection were also evaluated. Cognitive, behavioral, neurologic, audiometric, and speech and language evaluations were performed in 48 patients, including 17 congenitally infected children, 10 children with postnatal infection, and 21 uninfected control subjects. Mean IQ of the three groups of children did not differ significantly. Behavioral, neurologic, speech and language examinations similarly failed to distinguish differences among the three groups. Audiologic abnormalities were present in four congenitally infected children, including one child with a severe unilateral sensorineural loss; in none of the children was hearing loss functionally significant. No hearing abnormalities were detected in postnatally infected children. Although inapparent CMV infection can result in audiologic sequelae, the continued lack of cognitive, behavioral, and neurologic sequelae in these school-age children reemphasizes the need to focus attention on prevention of primary maternal CMV infection to avoid the potentially devastating effects of intrauterine CMV infection.