Controlling cell size through sizer mechanisms.
Controlling cell size through sizer mechanisms.
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DOI：
10.1016/j.coisb.2017.08.010
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发表时间：
2017-10-01
影响因子：
3.7
通讯作者：
Howard, Martin
中科院分区：
文献类型：
--
作者：
Facchetti, Giuseppe;Chang, Fred;Howard, Martin
细胞的大小部分取决于细胞生长和分裂之间的协调。这种协调是如何在机械上实现的仍然是未知的。然而，定量实验与计算建模一起重振了这一领域，并阐明了潜在的分子过程。大小稳态可以通过不同的调节模式来实现，包括“大小器”、“加法器”和“定时器”。“对于尺寸调节，细胞分裂周期直到达到最小尺寸才进行，这需要细胞监测自己的尺寸。在这里，我们强调了在确定分裂和芽殖酵母中的sizer机制方面的进展，显示了如何在生长过程中使用关键分子的积累或稀释来监测细胞大小。我们还讨论了一个潜在的作用，筛选器在细菌大小控制。
Cell size is partly determined through coordination between cell growth and division. How this coordination is achieved mechanistically remains mostly unknown. However, quantitative experiments together with computational modelling have reinvigorated the field and are elucidating underlying molecular processes. Size homeostasis may be achieved through different modes of regulation, including "sizers", "adders" and "timers." For sizer regulation, the cell division cycle does not proceed until a minimal size has been reached, requiring that the cell monitors its own size. Here, we highlight progress in defining sizer mechanisms in fission and budding yeasts showing how accumulation or dilution of key molecules can be used to monitor cell size during growth. We also discuss a potential role for sizers in bacterial size control.