Characterization of Focal Liver Lesions (FLL) with Acoustic Radiation Force Impulse (ARFI) Elastometry
Characterization of Focal Liver Lesions (FLL) with Acoustic Radiation Force Impulse (ARFI) Elastometry
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DOI：
10.1055/s-0029-1245565
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发表时间：
2010-08-01
影响因子：
3.4
通讯作者：
Goertz, R. S.
中科院分区：
文献类型：
--
作者：
Heide, R.;Strobel, D.;Goertz, R. S.
目的：声辐射力脉冲（ARFI）技术是一种新的组织弹性定量方法。本前瞻性试验研究的目的是评估局灶性肝病变（FLL）和周围肝实质ARFI弹性测量的作用。材料和方法：所有患者在B型超声不清楚FLL被分配到ARFI弹性测量（米/秒）。测量部位位于FLL内、瘤周组织和肝段VIII（肋间入路）。组织学和CEUS作为参考的表征lesions.Results：共81例患者入组，其中62例（39名女性，23名男性，平均年龄54岁）FLL可测量ARFI的手段。良性38例（61%），恶性24例（39%）。FLL的ARFI弹性测量值与肝实质的ARFI弹性测量值有显著差异（p < 0.001）。良性病变和恶性肿瘤的弹性测量结果具有统计学可比性（p = 0.28）。最低的ARFI值在局灶性脂肪保留中观察到，CCC中最高。只有局灶性脂肪保留和HCC显示FLL与瘤周组织或肝实质之间的负差异。在23%的肝脏病变，没有可靠的定量ARFI结果是由于错误的，不一致的或技术上失败的measurement.Conclusion：FLL变化ARFI弹性。然而，高ARFI值发生在良性和恶性病变，并不允许它们之间的区分。
Purpose: The technology of acoustic radiation force impulse (ARFI) represents an innovative method for the quantification of tissue elasticity. The aim of this prospective pilot study was to evaluate the role of ARFI elastometry of focal liver lesions (FLL) and the surrounding liver parenchyma.Materials and Methods: All patients with unclear FLL in B-mode ultrasound were assigned to ARFI elastometry (m/sec). Measurement sites were located within the FLL, in the peritumoral tissue and in hepatic segment VIII (intercostal approach). Histology and CEUS served as the reference for the characterization of the lesions.Results: A total of 81 patients were enrolled, of whom 62 patients (39 females, 23 males; mean age 54 years) had FLL measurable by means of ARFI. The lesions were: 38 benign (61%) and 24 malignant FLL (39%). The ARFI elastometric values of the FLL differed significantly from those of the liver parenchyma (p < 0.001). Elastometry of benign lesions and of malignant tumors showed statistically comparable results (p = 0.28). The lowest ARFI values were observed in focal fatty sparing and the highest in CCC. Only focal fatty sparing and HCC showed negative differences between FLL and peritumoral tissue or liver parenchyma. In 23% of the hepatic lesions, no reliable quantitative ARFI results were obtainable due to false, inconsistent or technically failed measurements.Conclusion: FLL vary in ARFI elastometry. However, high ARFI values occur in benign as well as in malignant lesions and do not permit differentiation between them.