Protective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds.
Protective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds.
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DOI：
10.1155/2015/343706
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发表时间：
2015
影响因子：
--
通讯作者：
Yamazaki T
中科院分区：
文献类型：
--
作者：
Ishihara Y;Takemoto T;Ishida A;Yamazaki T
外周内分泌腺合成和分泌的类固醇激素通过血脑屏障，在中枢神经系统中发挥作用。此外，大脑拥有固有的内分泌系统，并合成被称为神经类固醇的类固醇激素。越来越多的证据表明，神经活性类固醇可以保护中枢神经系统免受各种有害刺激。有报道表明，类固醇激素的神经保护作用可以减轻氧化应激。本文综述了神经活性类固醇，特别是17β-雌二醇和孕酮在不同病理条件下对中枢神经系统神经元损伤的抗氧化作用，并介绍了我们最近关于17β-雌二醇和孕酮对金属有机化合物、三丁基锡和甲基汞所致的氧化损伤的神经保护作用的研究结果。
Steroid hormones synthesized in and secreted from peripheral endocrine glands pass through the blood-brain barrier and play a role in the central nervous system. In addition, the brain possesses an inherent endocrine system and synthesizes steroid hormones known as neurosteroids. Increasing evidence shows that neuroactive steroids protect the central nervous system from various harmful stimuli. Reports show that the neuroprotective actions of steroid hormones attenuate oxidative stress. In this review, we summarize the antioxidative effects of neuroactive steroids, especially 17β-estradiol and progesterone, on neuronal injury in the central nervous system under various pathological conditions, and then describe our recent findings concerning the neuroprotective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds, tributyltin, and methylmercury.
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