Non-invasive estimation of muscle fibre size from high-density electromyography.
Non-invasive estimation of muscle fibre size from high-density electromyography.
复制标题
通过高密度肌电图无创估计肌纤维大小。
DOI：
10.1113/jp284170
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Casolo A
中科院分区：
文献类型：
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作者：
Casolo A
摘要由于肌纤维直径与动作电位沿肌纤维传播速度之间的生物物理关系，运动单位传导速度可作为人体肌纤维大小的无创性指标。然而，运动单位传导速度和纤维大小之间的关系只在动物模型和有侵入性肌肉内肌电记录的人类患者中得到间接评估，或者是从计算机模拟中数学推导出来的。通过结合先进的无创性记录活体运动单位活动的技术，即高密度表面肌电信号和肌肉组织取样的金标准技术，即肌肉活检，我们研究了从二头肌识别出的运动单位群体的传导速度与肌纤维直径之间的关系。我们证明了通过低系统偏差(分别为∼2%和∼4%)和相对较低的个体误差(分别为∼8%和∼16%)的传导速度估计来预测肌纤维直径(R2=0.66)和横截面积(R2=0.65)的可能性。拟议的神经肌肉接口在使用高密度肌电作为一种非侵入性工具来估计肌肉纤维大小方面开辟了新的前景，而不需要手术活检采样。高密度表面肌电信号用于评估肌肉纤维大小的非侵入性在监测儿童发育、衰老、空间和运动生理学的研究中可能是有用的，尽管所提出的方法的适用性和有效性需要在未来的研究中更直接地在这些特定人群中评估。由于肌肉纤维大小和动作电位沿肌膜的传播速度之间的生物物理关系，运动单位传导速度可以代表潜在的非侵入性候选活体肌肉纤维大小。这种关系以前已经在动物模型和人类中用侵入性技术进行过评估，或者它是从数学上推导出来的。通过将高密度表面肌电信号与肌肉活检相结合，在此，我们探讨了健康人运动单位群体的传导速度与肌纤维大小的关系。我们的结果证实，运动单位传导速度可以被认为是一种新的肌纤维大小的生物标志物，可以用来预测肌纤维直径和横截面积，系统偏差和个体误差都很小。所提出的神经肌肉接口为使用高密度肌电作为一种非侵入性工具来估计肌纤维大小开辟了新的前景，而不需要手术活检采样。
AbstractBecause of the biophysical relation between muscle fibre diameter and the propagation velocity of action potentials along the muscle fibres, motor unit conduction velocity could be a non‐invasive index of muscle fibre size in humans. However, the relation between motor unit conduction velocity and fibre size has been only assessed indirectly in animal models and in human patients with invasive intramuscular EMG recordings, or it has been mathematically derived from computer simulations. By combining advanced non‐invasive techniques to record motor unit activityin vivo, i.e. high‐density surface EMG, with the gold standard technique for muscle tissue sampling, i.e. muscle biopsy, here we investigated the relation between the conduction velocity of populations of motor units identified from the biceps brachii muscle, and muscle fibre diameter. We demonstrate the possibility of predicting muscle fibre diameter (R2= 0.66) and cross‐sectional area (R2= 0.65) from conduction velocity estimates with low systematic bias (∼2% and ∼4% respectively) and a relatively low margin of individual error (∼8% and ∼16%, respectively). The proposed neuromuscular interface opens new perspectives in the use of high‐density EMG as a non‐invasive tool to estimate muscle fibre size without the need of surgical biopsy sampling. The non‐invasive nature of high‐density surface EMG for the assessment of muscle fibre size may be useful in studies monitoring child development, ageing, space and exercise physiology, although the applicability and validity of the proposed methodology need to be more directly assessed in these specific populations by future studies.Key pointsBecause of the biophysical relation between muscle fibre size and the propagation velocity of action potentials along the sarcolemma, motor unit conduction velocity could represent a potential non‐invasive candidate for estimating muscle fibre sizein vivo.This relation has been previously assessed in animal models and humans with invasive techniques, or it has been mathematically derived from simulations.By combining high‐density surface EMG with muscle biopsy, here we explored the relation between the conduction velocity of populations of motor units and muscle fibre size in healthy individuals.Our results confirmed that motor unit conduction velocity can be considered as a novel biomarker of fibre size, which can be adopted to predict muscle fibre diameter and cross‐sectional area with low systematic bias and margin of individual error.The proposed neuromuscular interface opens new perspectives in the use of high‐density EMG as a non‐invasive tool to estimate muscle fibre size without the need of surgical biopsy sampling.