Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion
Diagnostic dilemma between medication-related osteonecrosis and oral squamous cell carcinoma in a mandibular lytic lesion
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DOI：
10.1016/j.bjoms.2017.08.005
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发表时间：
2017-11-01
影响因子：
1.8
通讯作者：
Rutherford, N.
中科院分区：
文献类型：
--
作者：
Tocaciu, S.;Breik, O.;Rutherford, N.
下颌骨溶骨性病变很常见，必须考虑两种重要的鉴别诊断：药物相关性颌骨坏死（MRONJ）和鳞状细胞癌（SCC）。对于有服用抗骨吸收药物史以及有肿瘤危险因素的患者，可能很难区分两者。我们描述了两个病例，由于临床和组织病理学特征混淆，下颌骨溶骨性病变未被充分鉴定为 MRONJ 或 SCC。我们还查阅了相关出版物以找出类似案例。在这里，我们讨论面对两种具有相似临床和组织病理学特征的不同病症时的临床困境。 (C) 2017 年英国口腔颌面外科医师协会。由爱思唯尔有限公司出版。保留所有权利。
Osteolytic lesions of the mandible are common, and there are two important differential diagnoses that must be considered: medication-related osteonecrosis of the jaws (MRONJ) and squamous cell carcinoma (SCC). In patients with a history of taking antiresorptive medication as well as risk factors for neoplasia it can be difficult to differentiate between the two. We describe two cases in both of which a mandibular osteolytic lesion was inadequately identified as either MRONJ or SCC because of confusing clinical and histopathological features. We also reviewed relevant publications to identify similar cases. Here we discuss our clinical dilemma when faced with two different conditions that present with similar clinical and histopathological features. (C) 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.