Noncontrast-enhanced time-resolved 4D dynamic intracranial MR angiography at 7T: A feasibility study
Noncontrast-enhanced time-resolved 4D dynamic intracranial MR angiography at 7T: A feasibility study
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DOI：
10.1002/jmri.25923
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发表时间：
2018-07-01
影响因子：
4.4
通讯作者：
Yan, Lirong
中科院分区：
文献类型：
--
作者：
Cong, Fei;Zhuo, Yan;Yan, Lirong
背景：基于材料自旋标记（ASL）的非对比增强4D MR血管造影（NCE 4D MRA）显示出表征脑血管疾病脑血管血流动力学的潜力。超高场理论上有利于ASL信号，其固有信噪比（SNR）增加，血液T-1延长，这可能改善4D MRA对血管的描绘。目的探讨在7T位置采用三维笛卡尔轨迹和SOS黄金角径向轨迹进行NCE四维磁共振成像的可行性。研究类型a前瞻性研究。研究对象6名正常人和8名动静脉畸形（AVM）患者。在3T和7T进行场强/序列4D MRA，具有笛卡尔和径向轨迹。评价由两名经验丰富的神经放射学家采用4分制对4D MRA主观图像质量进行评价。利用4D MRA和DSA对AVM成分的表征也采用Spetzler-Martin分级量表进行分级。计算scohen 's kappa系数，以评估每个4D MRA技术（笛卡尔和径向）中两个读者之间的一致性。采用Wilcoxon符号秩检验分别比较笛卡尔和径向轨迹、7T和3T之间的4D MRA主观图像质量评分。结果健康志愿者在7T时，笛卡尔（3.83 0.41）和径向（3.42 0.49）采集的4D MRA图像质量均达到良好至优异。然而，通过径向采集可以显著缩短扫描时间。7T 4D MRA（3.31 0.59）较3T（2.83 0.75）更能描绘AVM病变特征，尤其是静脉引流，但差异无统计学意义（P = 0.180）。结论基于ASL的7T四维MRA笛卡尔和SOS黄金角径向采集的可行性得到了验证。3T ~ 7T AVM的4D MRA临床评价表明，7T径向采集的4D MRA图像能很好地描绘AVM的特征，尤其是引流静脉。证据水平：2技术功效阶段2 [j]。的原因。2017年成像。
BackgroundArterial spin labeling (ASL) based-noncontrast-enhanced 4D MR angiography (NCE 4D MRA) shows potential in characterizing cerebrovascular hemodynamics in cerebrovascular disorders. Ultrahigh-field theoretically benefits ASL signal with increased inherent signal-to-noise ratio (SNR) and prolonged blood T-1, which may provide improved delineation of vasculature in 4D MRA.PurposeTo investigate the feasibility of NCE 4D MRA using 3D Cartesian trajectory and stack-of-stars (SOS) golden angle radial trajectory at 7T.Study TypeA prospective study.SubjectsSix normal volunteers and eight patients with arteriovenous malformation (AVM).Field Strength/SequenceNCE 4D MRA with Cartesian and radial trajectories were performed at 3T and 7T.AssessmentSubjective image quality of 4D MRA was evaluated using a 4-point scale by two experienced neuroradiologists. The characterization of AVM components with 4D MRA and DSA was also graded using the Spetzler-Martin grading scale.Statistical TestsCohen's kappa coefficient was calculated to evaluate the agreement between two readers within each 4D MRA technique (Cartesian and Radial). A Wilcoxon signed-rank test was performed to compare the subjective image quality scores of 4D MRA between Cartesian and radial trajectories, and between 7T and 3T, respectively.ResultsGood-to-excellent image quality was achieved in 4D MRA with both Cartesian (3.83 0.41) and radial (3.42 0.49) acquisitions in healthy volunteers at 7T. However, markedly reduced scan time was needed with radial acquisition. 4D MRA at 7T (3.31 0.59) shows better delineation of AVM lesion features, especially the vein drainage, compared with that of 3T (2.83 0.75), although no statistical significance was achieved (P = 0.180).Data ConclusionThe feasibility of ASL based 4D MRA at 7T with Cartesian and SOS golden angle radial acquisition was demonstrated. The clinical evaluation of 4D MRA in AVMs between 3T and 7T suggested 7T 4D MRA images acquired with radial acquisition demonstrate excellent delineation of AVM features, especially the draining veins. Level of Evidence: 2 Technical Efficacy Stage 2 J. Magn. Reson. Imaging 2017.