Effects of acute exercise on flow-mediated dilatation in healthy humans
Effects of acute exercise on flow-mediated dilatation in healthy humans
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DOI：
10.1152/japplphysiol.00450.2013
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发表时间：
2013-12-01
影响因子：
3.3
通讯作者：
Thijssen, Dick H. J.
中科院分区：
文献类型：
--
作者：
Dawson, Ellen A.;Green, Daniel J.;Thijssen, Dick H. J.
虽然运动训练对血管功能的影响已经得到了很好的研究，但对急性运动的影响知之甚少。本综述总结并整合了运动对动脉功能的急性影响相关论文中的知识，特别是通过血流介导的扩张（FMD）评估的内皮功能。我们认为，FMD（“最低点”）的立即减少发生在运动停止后不久，这是随后的（超）正常化反应。这种双相反应模式的最低值和（以上）正常化和持续时间的大小似乎受到许多因素的影响，包括运动刺激的性质（例如，类型、持续时间、强度），受试者群体（例如，培训与未培训），以及各种方法因素。这些因素对双相模式的影响最有可能是通过支持运动后FMD改变的刺激来介导的，包括剪切和氧化应激、动脉直径的变化和抗氧化状态。我们建议，这些刺激的组合协同作用，以平衡运动后的血管反应。最后，我们讨论了急性运动后双相反应的潜在（临床）相关性，因为即时最低点可能代表随后训练诱导适应的基本反应，但也可能代表导致“运动悖论”的心血管风险增加的短暂时期。"
Although the effects of exercise training on vascular function have been well studied, less is known about the effects of acute exercise bouts. This synthesis summarizes and integrates knowledge derived from papers relating acute impacts of exercise on artery function, specifically endothelial function assessed by flow-mediated dilatation (FMD). We propose that an immediate decrease in FMD ("nadir") occurs soon after exercise cessation and that this is followed by a (supra) normalization response. The magnitude of the nadir and (supra) normalization and duration of this biphasic pattern of response appears to be influenced by numerous factors, including the nature of the exercise stimulus (e.g., type, duration, intensity), the subject population (e.g., trained vs. untrained), and various methodological factors. The impact of these factors on the biphasic pattern are most likely mediated through stimuli that underpin altered FMD postexercise, including shear and oxidative stress, changes in arterial diameter, and antioxidant status. We propose that a combination of these stimuli act synergistically to balance the vasomotor responses postexercise. Finally, we discuss the potential (clinical) relevance of the biphasic response after acute exercise, as the immediate nadir may represent an essential response for subsequent training-induced adaptations but may also represent a transient period of increased cardiovascular risk leading to the "exercise paradox."