Blood Pressure, Heart Rate, and Plasma Catecholamines in Normal and Hypertensive Children and their Siblings at Rest and After Standing
Blood Pressure, Heart Rate, and Plasma Catecholamines in Normal and Hypertensive Children and their Siblings at Rest and After Standing
复制标题
正常儿童和高血压儿童及其兄弟姐妹休息和站立后的血压、心率和血浆儿茶酚胺
作者：
W. Mccrory;A. A. Klein;R. Rosenthal
对19例临界性高血压(SBP-135 mm Hg，DBP-80 mm Hg)、9例明显高血压(SH)(SBP-150 mm Hg，DBP-95 mm Hg)、14例血压正常的同胞(NS)(SBP-113 mm Hg，DBP-mm Hg)和21例年龄匹配的正常血压对照组(NC)的心率、收缩压、舒张压、血浆去甲肾上腺素(NE)和肾上腺素(E)水平进行了比较DBP-61毫米汞柱)。BH组和SH组静息血浆NE水平分别为454个/、0.001个/和384个/，显著高于NC组(281个/)和NS组(309个/)，且BH组50°、SH组28°和NS组7°组血浆NE水平均高于NC平均值2 SD以上。血浆E水平相似。站立时，NC组平均动脉压(MAP)上升13.7 mm Hg，BH组上升3.9 mm Hg，NS组上升2.8 mm Hg，SH组下降7.3 mm Hg。这些差异反映了研究组受试者经常出现低血压反应，而NC中没有观察到这一点。高血压病患者血浆NE随站立时间的平均升高幅度有所减弱，较正常对照组增加40°~50°。BH组和NS组SBP与静息和立位时血浆NE水平呈正相关。这些观察结果支持了一种假设，即在一组年轻高血压患者中存在肾上腺素能交感神经系统(SNS)活动改变，并可能是他们高血压的一个促成因素。在一些血压正常的兄弟姐妹中发现了类似的SNS活动，这表明可能与遗传因素有关。(1982年高血压4：507-513)
Heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), plasma norepinephrine (NE), and epinephrine (E) levels at rest and in response to orthostatic stress of quiet standing were compared in 19 subjects with borderline hypertension (BH) (SBP-135 mm Hg, DBP-80 mm Hg), nine with significant hypertension (SH) (SBP-150 mm Hg, DBP-95 mm Hg), 14 normotensive siblings (NS) of hypertensives (SBP-113 mm Hg, DBP-64 mm Hg), and 21 age-matched normotensive controls (NC) (SBP-116 mm Hg, DBP-61 mm Hg). Group resting plasma NE levels were significantly higher in BH (454/, p < 0.001/) and SH (384/, p < 0.01/) than in NC (281/) or NS (309/), and more than 2 SD above the NC mean value in 50° of BH, 28° of SH, and 7° of NS. Plasma E levels were similar. On standing, mean arterial pressure (MAP) rose 13.7 mm Hg in NC, 3.9 mm Hg in BH, and 2.8 mm Hg in NS, and fell 7.3 mm Hg in SH. These differences reflect the frequent occurrence of hypotensive responses in study group subjects, which were not observed in NC. The mean rise in plasma NE with standing was blunted in hypertensives, increasing 40° to 50° compared with 95° in NC. In BH and NS, SBP was positively correlated with plasma NE levels at rest and with standing. These observations offer support for the hypothesis that altered adrenergic sympathetic nervous system (SNS) activity is present in a subgroup of young hypertensives and can be a contributing factor to their hypertension. Findings of similar SNS activity in some normotensive siblings suggest that genetic factors might be involved. (Hypertension 4:507–513, 1982)