Components of airway hyperresponsiveness and their associations with inflammation and remodeling in mice
Components of airway hyperresponsiveness and their associations with inflammation and remodeling in mice
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DOI：
10.1016/j.jaci.2006.12.623
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发表时间：
2007-04-01
影响因子：
14.2
通讯作者：
Inman, Mark D.
中科院分区：
文献类型：
--
作者：
Southam, David S.;Ellis, Russ;Inman, Mark D.
背景：哮喘气道发生包括炎症和重塑在内的病理改变。然而，它们对气道高反应性（AHR）组成部分的相对贡献尚不清楚。目的：试图将AHR划分为离散的免疫介导和结构重塑成分，我们对最大呼吸系统阻力、气道反应性和气道敏感性的发生、进展和持续进行了详细的时间过程。方法：小鼠暴露于持续持续的过敏原持续时间增加评估气道功能，形态学和炎症。结果：过敏原暴露导致AHR所有指数的升高，并在慢性过敏原暴露后持续至少4周
Background: Pathologic changes, including inflammation and remodeling, occur in the asthmatic airway. However, their relative contribution to the components of airway hyperresponsiveness (AHR) remains unclear.Objective: Attempting to delineate AHR into discrete immune-mediated and structural remodeling components, we performed a detailed time course of the development, progression, and persistence of maximal respiratory system resistance, airway reactivity, and airway sensitivity. Methods: Mice exposed to increasing durations of persistent allergen were assessed for airway function, morphometry, and inflammation.Results: Allergen exposure resulted in increases for all indices of AHR that persisted for at least 4 weeks after chronic allergen exposure (P