Stimulation of growth factor synthesis by electric and electromagnetic fields
Stimulation of growth factor synthesis by electric and electromagnetic fields
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DOI：
10.1097/01.blo.0000118698.46535.83
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发表时间：
2004-02-01
影响因子：
4.2
通讯作者：
Simon, BJ
中科院分区：
文献类型：
--
作者：
Aaron, RK;Boyan, BD;Simon, BJ
生物物理输入，包括电场和电磁场，调节结缔组织细胞中结构性细胞外基质（ECM）蛋白的基因表达，导致软骨和骨生成增加。在体内模型和临床情况下，这可以表现为修复的增强和修复组织的机械性能的增加。生物物理输入调节细胞功能的机制是本次审查的主题。在细胞膜上的电场和电磁场的生物物理相互作用还没有得到很好的理解，需要大量的额外研究。本文综述了跨膜信号传导、通道激活和受体刺激或阻断的相关信息。了解物理相互作用和跨膜信号传导将很可能是必要的，以建立给药模式和提高疗效。已经产生了相当多的信息活动的中介机制-生长因子刺激。电场和电磁场增加生长因子的基因表达和合成，这可能通过自分泌和旁分泌信号传导起到放大场效应的作用。电场和电磁场可以产生生长因子的持续上调，其增强但不扰乱软骨内骨形成。在信号转导和生长因子合成领域的进展非常迅速，并提出了未来的发展方向。
Biophysical input, including electric and electromagnetic fields, regulate the expression of genes in connective tissue cells for structural extracellular matrix (ECM) proteins resulting in an increase in cartilage and bone production. In in vivo models and clinical situations, this can be manifested as enhanced repair and a gain in mechanical properties of the repairing tissues. The mechanisms by which cell functions are regulated by biophysical input is the subject of this review. Biophysical interactions of electric and electromagnetic fields at the cell membrane are not well understood and require considerable additional study. We review information on transmembrane signaling, channel activation and receptor stimulation or blockade. Understanding physical interactions and transmembrane signaling will most likely be necessary to establish dosing paradigms and improve therapeutic efficacy. Considerable information has been generated on an intermediary mechanism of activity - growth factor stimulation. Electric and electromagnetic fields increase gene expression for, and synthesis of, growth factors and this may function to amplify field effects through autocrine and paracrine signaling. Electric and electromagnetic fields can produce a sustained upregulation of growth factors, which enhance, but do not disorganize endochondral bone formation. Progress in the areas of signal transduction and growth factor synthesis is very rapid and future directions are suggested.