Neurodevelopmental Outcomes in Preterm Infants: Comparison of Infants with and without Diffuse Excessive High Signal Intensity on MR Images at Near-term-equivalent Age
Neurodevelopmental Outcomes in Preterm Infants: Comparison of Infants with and without Diffuse Excessive High Signal Intensity on MR Images at Near-term-equivalent Age
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DOI：
10.1148/radiol.12111615
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发表时间：
2012-05-01
期刊：
影响因子：
19.7
通讯作者：
Park, Won Soon
中科院分区：
文献类型：
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作者：
Jeon, Tae Yeon;Kim, Ji Hye;Park, Won Soon
目的：为了比较早产儿与弥漫性过高信号强度（DEHSI）和那些没有DEHSI的磁共振（MR）images.Materials和方法的神经发育结果之间的关联，与其他白色物质lesions.Materials：这项回顾性研究是由机构审查委员会批准，并要求获得知情同意书被免除。高危早产儿（n = 126）谁接受了筛选脑MR成像在近足月相当的年龄被分为两组，根据DEHSI的存在。比较两组18至24个月婴儿发育Bayley量表-II、脑瘫的存在和感觉神经损伤。其他白色病变（囊性脑软化、点状病变、体积丢失、脑室扩张和髓鞘形成延迟）的MR表现与后续结果的相关性也进行了分析。结果：DEHSI是目前在75%（95 126）的婴儿使用精确的logistic回归分析和Fisher精确test.Results的结果进行了评价。随后的神经发育结果在两组之间没有显著差异。与白色物质正常的婴儿相比，DEHSI和其他白色物质病变的婴儿更常见于严重运动迟缓和脑瘫（分别为P = 0.001和P <0.001）。在其他白色病变中，囊性脑软化（比值比，19.6; 95%置信区间：1.3，333.3）和点状病变（比值比，90.9; 95%可信区间：6.4，1000）是脑性瘫痪的显著预测因子。尽管在近足月相当年龄的早产儿中，MR成像的DEHSI发生率很高（75%），但DEHSI不能预测以下不良结局。囊性脑软化和点状病变是脑性瘫痪更重要的预测因素。(C)RSNA，2012年
Purpose: To compare the neurodevelopmental outcomes between preterm infants with diffuse excessive high signal intensity (DEHSI) and those without DEHSI on magnetic resonance (MR) images, in association with other white matter lesions.Materials and Methods: This retrospective study was approved by the institutional review board, and requirement to obtain informed consent was waived. High-risk preterm infants (n = 126) who underwent screening brain MR imaging at near-term-equivalent age were classified into two groups according to the presence of DEHSI. Bayley Scales of Infant Development-II, presence of cerebral palsy, and neurosensory impairment between 18 and 24 months of age were compared between the two groups. The associations of MR findings of other white matter lesions (cystic encephalomalacia, punctate lesions, loss of volume, ventricular dilatation, and delayed myelination) and subsequent outcomes were also analyzed. Outcome data were evaluated by using exact logistic regression analyses and Fisher exact test.Results: DEHSI was present in 75% (95 of 126) of infants. Subsequent neurodevelopmental outcomes did not differ significantly between the two groups. Severe motor delay and cerebral palsy were more common in infants with both DEHSI and other white matter lesions as compared with infants with normal white matter (P = .001 and P < .001, respectively). Among other white matter lesions, cystic encephalomalacia (odds ratio, 19.6; 95% confidence interval: 1.3, 333.3) and punctate lesions (odds ratio, 90.9; 95% confidence interval: 6.4, 1000) were significant predictors of cerebral palsy.Conclusion: Although the incidence of DEHSI was high (75%) in preterm infants at near-term-equivalent age MR imaging, DEHSI was not predictive of following adverse outcomes. Cystic encephalomalacia and punctate lesions were more significant predictors of cerebral palsy. (C) RSNA, 2012