Epidemiology of systemic lupus erythematosus: an update.
Epidemiology of systemic lupus erythematosus: an update.
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DOI：
10.1097/bor.0000000000000480
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发表时间：
2018-03
影响因子：
5.1
通讯作者：
Petri M
中科院分区：
文献类型：
--
作者：
Stojan G;Petri M
系统性红斑狼疮（SLE）是一种典型的系统性自身免疫性疾病，在世界范围内不同种族、种族和年龄组中具有显著的疾病负担。对SLE的病理生理学理解不断发展，因此需要更好地定义疾病本身，了解不同受影响人群的风险，并确定多年来造成损害的因素。不仅在美国，而且在欧洲、中东和亚洲，对不同种族和少数群体SLE发病率和患病率的更准确估计为世界各地的疾病负担提供了新的见解。尽管在治疗方面取得了进展，但SLE患者的死亡率仍然很高，具有显著的地理差异。性别、人种和种族显著影响SLE的发病率、患病率、损害累积和死亡率。
Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease with a significant disease burden across the world among different ethnic, racial and age groups. The pathophysiological understanding of SLE is constantly evolving and with it, the need for a better definition of the disease itself, for understanding the risk among the different affected populations, and for identifying the factors responsible for the damage accrual through the years. More accurate estimates of incidence and prevalence of SLE among different ethnicities and minority groups not only in the USA, but in Europe, Middle East, and Asia have provided new insights into the disease burden around the world. Despite advances in treatment, mortality among SLE patients remains high with significant geographic variations. Gender, race, and ethnicity significantly affect SLE incidence, prevalence, damage accrual, and mortality.