Distance-dependent differences in synapse number and AMPA receptor expression in hippocampal CA1 pyramidal neurons
Distance-dependent differences in synapse number and AMPA receptor expression in hippocampal CA1 pyramidal neurons
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DOI：
10.1016/j.neuron.2006.03.022
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发表时间：
2006-05-04
期刊：
影响因子：
16.2
通讯作者：
Geinisman, Yuri
中科院分区：
文献类型：
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作者：
Nicholson, Daniel A.;Trana, Rachel;Geinisman, Yuri
贯穿树突的突触影响神经元输出的能力对大脑中的信息处理至关重要。然而，当突触电位沿着树突向胞体传播时，突触电位显著减弱。为了检测CA1锥体神经元上的兴奋性轴棘突触是否补偿了它们与胞体的距离，以抵消这种树突过滤，我们研究了三个递进远端区域的轴棘突触数量和受体表达：放射层近端和远端，以及腔隙分子层(SLM)。我们发现，穿孔突触的比例随着距离胞体的距离而增加，它们的AMPAR，而不是NMDAR，在远端SR表达最高，在SLM表达最低。根据这些结果建立的锥体神经元的计算模型表明，它们是由于SR的电导缩放和SLM的树突棘波的特殊使用，以最大限度地减少距离对突触效率的影响。
The ability of synapses throughout the dendritic tree to influence neuronal output is crucial for information processing in the brain. Synaptic potentials attenuate dramatically, however, as they propagate along dendrites toward the soma. To examine whether excitatory axospinous synapses on CA1 pyramidal neurons compensate for their distance from the soma to counteract such dendritic filtering, we evaluated axospinous synapse number and receptor expression in three progressively distal regions: proximal and distal stratum radiatum (SR), and stratum lacunosum-moleculare (SLM). We found that the proportion of perforated synapses increases as a function of distance from the soma and that their AMPAR, but not NMDAR, expression is highest in distal SR and lowest in SLM. Computational models of pyramidal neurons derived from these results suggest that they arise from the compartment-specific use of conductance scaling in SR and dendritic spikes in SLM to minimize the influence of distance on synaptic efficacy.