Cholesterol transport and steroidogenesis by the corpus luteum.
Cholesterol transport and steroidogenesis by the corpus luteum.
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DOI：
10.1186/1477-7827-1-90
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发表时间：
2003-11-10
期刊：
影响因子：
--
通讯作者：
Devoto, Luigi
中科院分区：
文献类型：
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作者：
Christenson, Lane K;Devoto, Luigi
黄体合成孕酮对于早期妊娠的建立和维持是必不可少的。黄体类固醇生成的调节可分为三个主要事件：黄体化（即，排卵卵泡的转换）、黄体退化和妊娠诱导的黄体维持/挽救。虽然控制这些事件并决定最终类固醇终产物的因素在不同物种之间差异很大，但黄体（黄体化的卵泡膜细胞和颗粒细胞）的组成以及参与类固醇生成途径的酶和蛋白质在所有物种中相对相似。本文综述了影响黄体类固醇生成的关键因素以及黄体类固醇生成功能调节的一些新的令人兴奋的观察结果。
The synthesis of progesterone by the corpus luteum is essential for the establishment and maintenance of early pregnancy. Regulation of luteal steroidogenesis can be broken down into three major events; luteinization (i.e., conversion of an ovulatory follicle), luteal regression, and pregnancy induced luteal maintenance/rescue. While the factors that control these events and dictate the final steroid end products are widely varied among different species, the composition of the corpus luteum (luteinized thecal and granulosa cells) and the enzymes and proteins involved in the steroidogenic pathway are relatively similar among all species. The key factors involved in luteal steroidogenesis and several new exciting observations regarding regulation of luteal steroidogenic function are discussed in this review.