MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma
MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma
复制标题
DOI：
10.1158/1078-0432.ccr-05-2814
复制
发表时间：
2006-07-15
影响因子：
11.5
通讯作者：
Yonezawa, Suguru
中科院分区：
文献类型：
--
作者：
Tamada, Shugo;Shibahara, Hiroaki;Yonezawa, Suguru
目的：许多肝外胆管癌（EHBDC）患者预后较差。我们已经报道MUC4是胰腺腺癌和肝内胆管癌的一个新的预后因子。本研究的目的是评估MUC4表达在EHBDC中的预后意义。实验设计：我们使用免疫组织化学方法检测了MUC4在70例EHBDC患者组织中的表达谱。MUC4是一种类似MUC1的膜粘蛋白。此外，MUC4是受体酪氨酸激酶ErbB2的膜内配体，与p27的调控有关。我们比较了MUC4与MUC1、ErbB2或p27在EHBDC中的表达。结果：MUC4在70例EHBDC患者中有36例表达。MUC4表达与MUC1、ErbB2、p27表达无显著相关性。19例MUC4高表达患者（>= 20%的癌细胞染色）的生存率明显低于51例MUC4低表达患者（低于20%的癌细胞染色，P = 0.0072）。单因素分析显示，MUC4高表达（P = 0.0072）、MUC1高表达（P = 0.0092）、组织学分级（P = 0.0029）、手术切缘受损伤（P = 0.0137）、淋巴结转移（P = 0.0036）是具有统计学意义的危险因素。多因素逐步回归分析显示，MUC4高表达（P = 0.0195）和手术切缘受援（P = 0.0358）是具有统计学意义的独立危险因素。结论：MUC4在EHBDC中的表达是不良预后的一个新的独立因素，可以预测EHBDC患者的预后。
Purpose: Many of the patients with extrahepatic bile duct carcinoma (EHBDC) show a poor outcome. We have reported that MUC4 is a novel prognostic factor of pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma. The aim of this study is to evaluate the prognostic significance of MUC4 expression in EHBDC.Experimental Design: We examined the expression profile of MUC4 in EHBDC tissues from 70 patients using immunohistochemistry. MUC4 is a membrane mucin like MUC1. In addition MUC4 is an intramembrane ligand for receptor tyrosine kinase ErbB2 and is related with regulation of p27. We compared the MUC4 expression with MUC1, ErbB2, or p27 expression in EHBDC.Results: MUC4 was expressed in 36 of the 70 patients with EHBDC. There was no significant correlation between the MUC4 expression and MUC1, ErbB2, or p27 expression. The survival of 19 patients with high MUC4 expression (>= 20% of carcinoma cells stained) was significantly worse than that of the 51 patients with low MUC4 expression (under 20% of carcinoma cells stained; P = 0.0072). The univariate analysis showed that high MUC4 expression (P = 0.0072), high MUC1 expression (P = 0.0092), histologic grading (P = 0.0029), surgical margin involvement (P = 0.0137), and nodal metastasis (P = 0.0036) were statistically significant risk factors. The backward stepwise multivariate analysis showed that high MUC4 expression (P = 0.0195) and surgical margin involvement (P = 0.0358) were statistically significant independent risk factors.Conclusions: MUC4 expression in EHBDC is a new independent factor for poor prognosis and predicts the outcome of patients with EHBDC.