Study of the effect of vascular endothelial growth factor (VEGF) C(+405)G (rs2010963) single nucleotide polymorphism on the development of esophageal and gastric varices and risk of variceal bleeding in cirrhotic hepatitis C virus (HCV) patients (VEGF) C(+405)G IN esophageal and gastric varices
Study of the effect of vascular endothelial growth factor (VEGF) C(+405)G (rs2010963) single nucleotide polymorphism on the development of esophageal and gastric varices and risk of variceal bleeding in cirrhotic hepatitis C virus (HCV) patients (VEGF) C(+405)G IN esophageal and gastric varices
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DOI：
10.1186/s43066-021-00160-1
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发表时间：
2022-01-17
影响因子：
0.8
通讯作者：
Abo-Yossef, Rania
中科院分区：
文献类型：
--
作者：
Aboismail, Ashraf;El-Shazly, Mohamed;Abo-Yossef, Rania
HCV感染是世界范围内慢性肝脏疾病的主要原因。食管和胃静脉曲张是常见的肝硬化患者由于合并门静脉高压。静脉曲张出血是一种主要的失代偿事件，具有高发病率和死亡率。肝硬化发生的内皮功能障碍，促进肝硬化、门静脉高压的发展，并增加肝内血管阻力。VEGF家族成员是血管发育和功能的主要调节因子。结果研究对象为亚历山大大学附属医院热带内科收治的90例患者：经内窥镜证实有静脉曲张的肝硬化患者30例（A组），无静脉曲张的肝硬化患者30例（B组），健康对照30例（C组）。所有患者均接受详细的病史和全面的临床检查、实验室检查、腹部超声检查、上消化道内镜检查，并采用5′核酸酶法对VEGF C(+405)G （rs2010963）进行基因分型。VEGF C(+405)G (rs2010963) GG基因型与较高的食管和胃静脉曲张患病率以及较高的出血风险相关。结论VEGF C(+405)G （rs2010963）是食管静脉曲张、胃静脉曲张的重要遗传决定因素，与静脉曲张出血风险相关。该SNP的基因检测将有助于预测食管和胃静脉曲张及出血风险。
Background HCV infection is a major worldwide cause of chronic liver diseases. Esophageal and gastric varices are common in cirrhotic patients due to concomitant portal hypertension. Variceal hemorrhage is a major decompensating event with high morbidity and mortality. Endothelial dysfunction, occurring in cirrhosis, facilitates the development of liver cirrhosis, portal hypertension and contributes to increased intrahepatic vascular resistance.(.)VEGF family members are major regulators of blood vessel development and function. Results The study was conducted on 90 subjects admitted to Tropical Medicine Department, Alexandria Main University Hospital: 30 cirrhotic patients with endoscopically proven varices (group A), 30 cirrhotic patients without varices (group B), and 30 healthy controls (group C). All patients was subjected to detailed history taking and thorough clinical examination, laboratory investigations, ultrasound abdomen, upper gastrointestinal endoscopy, and genotyping for VEGF C(+405)G (rs2010963) by 5 ' nuclease assay. The VEGF C(+405)G (rs2010963) GG genotype was associated with higher prevalence of esophageal and gastric varices and higher bleeding risk. Conclusion VEGF C(+405)G (rs2010963) is an important genetic determinant of esophageal varices, gastric varices, and correlates with variceal bleeding risk. Genetic testing of this SNP would be useful in prediction of esophageal and gastric varices and bleeding risk.