Structural morphology of renal vasculature
Structural morphology of renal vasculature
复制标题
DOI：
10.1152/ajpheart.00814.2005
复制
发表时间：
2006-07-01
影响因子：
4.8
通讯作者：
Smith, Nicolas P.
中科院分区：
文献类型：
--
作者：
Nordsletten, David A.;Blackett, Shane;Smith, Nicolas P.
提出了一种自动分割肾脏图像的方法，并将其应用于两幅肾脏CT图像。采用20 μ m体素分辨率图像，对大鼠肾血管进行了动脉和静脉树的分割，分辨出半径小至30 μ m的血管。对肾血管子树的高分辨率4 μ m体素图像进行了分割，其中血管径向值低至10 μ m。使用迭代方案对每个子树应用Strahler排序，以整合来自两个分割模型的信息，以重建整个血管树的完整拓扑。对分配订单的误差分析量化了整个模型的排序过程的鲁棒性。按照顺序报道了完整的动脉和静脉树的径向、长度和连通性数据。在单个动脉和静脉之间观察到大量的平行，平行血管半径的比例通过幂律量化。建立了与默里定律的强相关性，为“最小功”假设提供了令人信服的证据。结果与基于“最小剪切力”原则的理论分支角公式进行了比较，结果不确定。收集到的肾血管树的三维重建可以免费获得(1)，用于进一步研究肾脏生理学和建模研究。
An automatic segmentation technique has been developed and applied to two renal micro-computer tomography (CT) images. With the use of a 20-mu m voxel resolution image, the arterial and venous trees were segmented for the rat renal vasculature, distinguishing resolving vessels down to 30 mu m in radius. A higher resolution 4-mu m voxel image of a renal vascular subtree, with vessel radial values down to 10 mu m, was segmented. Strahler ordering was applied to each subtree using an iterative scheme developed to integrate information from the two segmented models to reconstruct the complete topology of the entire vascular tree. An error analysis of the assigned orders quantified the robustness of the ordering process for the full model. Radial, length, and connectivity data of the complete arterial and venous trees are reported by order. Substantial parallelism is observed between individual arteries and veins, and the ratio of parallel vessel radii is quantified via a power law. A strong correlation with Murray's Law was established, providing convincing evidence of the "minimum work" hypothesis. Results were compared with theoretical branch angle formulations, based on the principles of "minimum shear force," were inconclusive. Three-dimensional reconstructions of renal vascular trees collected are made freely available(1) for further investigation into renal physiology and modeling studies.