AMNIOTIC-FLUID STEROID-LEVELS - FETUSES WITH ADRENAL-HYPERPLASIA, 46,XXY FETUSES, AND NORMAL FETUSES
AMNIOTIC-FLUID STEROID-LEVELS - FETUSES WITH ADRENAL-HYPERPLASIA, 46,XXY FETUSES, AND NORMAL FETUSES
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DOI：
10.1001/archpedi.1982.03970390032010
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发表时间：
1982-01-01
影响因子：
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通讯作者：
MIGEON, CJ
中科院分区：
文献类型：
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作者：
CARSON, DJ;OKUNO, A;MIGEON, CJ
睾酮、雄烯二酮、脱氢表雄酮（DHA）、DHA硫酸盐（DHAS）、孕酮、17 α-在羊水穿刺术或选择性剖宫产术中获得的[人]羊水中测定羟孕酮（17-OHP）和氢化可的松。在妊娠15 - 21周，雄性胎儿的睾酮和雄烯二酮浓度显著高于雌性胎儿，但在近足月（36-40周）则无显著差异。在两种性别中，随着胎龄的增加，黄体酮和17-OHP浓度下降，而DHA、DHAS和氢化可的松浓度显着增加。先天性肾上腺皮质增生症（CAH）女性胎儿的羊水17-OHP、睾酮、DHA和雄烯二酮水平在孕中期比孕晚期升高。三个有CAH风险但未受影响的女性胎儿的类固醇浓度正常。2例Klinefelter综合征胎儿的类固醇浓度未见异常。
Concentrations of testosterone, androstenedione, dehydroepiandrosterone (DHA), DHA sulfate (DHAS), progesterone, 17.alpha.-hydroxyprogesterone (17-OHP) and hydrocortisone were determined in [human] amniotic fluid obtained at amniocentesis or at elective cesarean section. Male fetuses had significantly higher concentrations of testosterone and androstenedione than female fetuses had between 15 and 21 wk gestation, but not near term (36-40 wk). In both sexes progesterone and 17-OHP concentrations fell and DHA, DHAS, and hydrocortisone concentrations increased significantly with advancing gestational age. Amniotic fluid 17-OHP, testosterone, DHA and androstenedione levels from female fetuses with congenital adrenal hyperplasia (CAH) were more elevated in the 2nd trimester than in the 3rd. Three female fetuses at risk for CAH, but not affected, had normal steroid concentrations. Steroid concentrations from 2 fetuses with Klinefelter''s syndrome were not abnormal.