MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0
MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0
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DOI：
10.1093/molbev/mst197
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发表时间：
2013-12-01
影响因子：
10.7
通讯作者：
Kumar, Sudhir
中科院分区：
文献类型：
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作者：
Tamura, Koichiro;Stecher, Glen;Kumar, Sudhir
我们宣布发布分子进化遗传学分析（MEGA）软件的高级版本，该软件目前包含用于构建序列比对，推断系统发育历史和进行分子进化分析的设施。在6.0版本中，MEGA现在支持时间树的推断，因为它实现了RelTime方法来估计一个分支中所有分支点的发散时间。MEGA6中的新Timetree Wizard通过提供图形用户界面（GUI）来逐步指定时序和校准约束，从而促进了此Timetree推断。该版本还包含增强的算法来搜索进化标准下的最佳树，并实现了更先进的内存管理，可以将MEGA可以应用的序列数据集的大小增加一倍。MEGA6的GUI和命令行版本都可以从www.megasoftware.net免费下载。
We announce the release of an advanced version of the Molecular Evolutionary Genetics Analysis (MEGA) software, which currently contains facilities for building sequence alignments, inferring phylogenetic histories, and conducting molecular evolutionary analysis. In version 6.0, MEGA now enables the inference of timetrees, as it implements the RelTime method for estimating divergence times for all branching points in a phylogeny. A new Timetree Wizard in MEGA6 facilitates this timetree inference by providing a graphical user interface (GUI) to specify the phylogeny and calibration constraints step-by-step. This version also contains enhanced algorithms to search for the optimal trees under evolutionary criteria and implements a more advanced memory management that can double the size of sequence data sets to which MEGA can be applied. Both GUI and command-line versions of MEGA6 can be downloaded from www.megasoftware.net free of charge.