Cortical maturation in normal and abnormal fetuses as assessed with prenatal MR imaging
Cortical maturation in normal and abnormal fetuses as assessed with prenatal MR imaging
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DOI：
10.1148/radiology.210.3.r99mr47751
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发表时间：
1999-03-01
期刊：
影响因子：
19.7
通讯作者：
Barnes, PD
中科院分区：
文献类型：
--
作者：
Levine, D;Barnes, PD
目得：建立外观正常胎儿皮质发育在子宫内，并比较它与外观异常皮质development.MATERIALS和METHODS：磁共振（MR）图像的大脑在53个正常和40个异常胎儿在14-38周胎龄（GA）进行了审查。GA在MR成像可视化的裂缝或沟的时间进行了比较与CA指南的基础上neuroanatomical studies.RESULTS：在正常胎儿，脑沟标志出现在MR图像上的顺序预测通过使用解剖研究，与0-8周滞后的MR成像可视化的脑沟相比，报告的时间可视化的脑沟在解剖标本。当界标按GAs范围分组时，在53个正常胎儿中的50个（94%）中，在9个胎儿中的5个中，（56%，P < .05），31例胎儿中有24例有孤立性轻度脑室扩大，结论：正常胎儿皮质成熟在MR成像遵循一个可预测的过程，是稍微延迟与神经解剖标本中描述的。这种成熟往往进一步延迟胎儿与中枢神经系统异常。
PURPOSE: To establish the appearance of normal fetal cortical development in utero and compare it with the appearance of abnormal cortical development.MATERIALS AND METHODS: Magnetic resonance (MR) images of the brain in 53 normal and 40 abnormal fetuses at 14-38 weeks gestational age (GA) were reviewed. The GAs at the time of MR imaging visualization of the fissures or sulci were compared with the CA guidelines based on neuroanatomic studies.RESULTS: In normal fetuses, the sulcation landmarks appeared on MR images in the order predicted by using anatomic studies, with a 0-8-week lag in the MR imaging visualization of the sulci compared with the reported time of visualization of the sulci in anatomic specimens. When landmarks were grouped by range of GAs, the expected MR imaging sulcation landmarks in the group with younger GAs than the actual CA were seen in 50 of 53 (94%) normal fetuses, in five of nine fetuses (56%, P < .05) with isolated mild ventriculomegaly, and in 24 of 31 fetuses (77%, P < .05) with other CNS anomalies.CONCLUSION: Normal fetal cortical maturation at MR imaging follows a predictable course that is slightly delayed compared with that described in neuroanatomic specimens. This maturation is often further delayed in fetuses with CNS abnormalities.