Early experience and parent-of-origin-specific effects influence female reproductive success in mice
Early experience and parent-of-origin-specific effects influence female reproductive success in mice
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DOI：
10.1098/rsbl.2006.0457
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发表时间：
2006-06-22
期刊：
影响因子：
3.3
通讯作者：
Johnstone, Rufus A.
中科院分区：
文献类型：
--
作者：
Hager, Reinmar;Johnstone, Rufus A.
最近对哺乳动物的研究调查父母的起源特定的影响，如基因组印记和母亲的影响已经证明了他们的影响，短期措施的健身，如后代的生长。然而，长期健身的后果，父母的原产地的具体影响和他们的作用以外的直接母子互动仍然在很大程度上未被探索。在这里，我们表明，雌性小鼠交配的男性，继承了相同的一套父亲和母亲的基因，因为自己有一个更高的繁殖成功率比女性交配的男性互惠基因型。此外，我们表明，个人经历的早期社会环境影响其繁殖成功。与无血缘关系的兄弟姐妹在一个混合的窝提出了一个随后较低的生殖成功比那些被培养在一起，与他们所有的生物兄弟姐妹在未混合的窝。我们的研究结果突出了父母的起源特定的影响和条件在早期发展对哺乳动物的长期生殖成功的重要影响，并表明父母的起源特定的影响可能提供了潜在的机制，例如，在交配选择的基因型之间的有益的共适应。
Recent studies on mammals investigating parent-of-origin-specific effects such as genomic imprinting and maternal effects have demonstrated their impact on short-term measures of fitness, for example offspring growth. However, the long-term fitness consequences of parent-of-origin-specific effects and their role outside the immediate mother-offspring interaction remain largely unexplored. Here, we show that female mice mated to males that inherited the same set of paternal and maternal genes as themselves have a higher reproductive success than females mated to males of reciprocal genotype. Furthermore, we demonstrate that the early social environment experienced by an individual influences its reproductive success. Females raised with unrelated siblings in a mixed litter had a subsequent lower reproductive success than those that were fostered together with all their biological siblings in unmixed litters. Our results highlight the important influence of parent-of-origin-specific effects and conditions in early development on long-term reproductive success in mammals and suggest that parent-of-origin-specific effects may provide the underlying mechanism for beneficial coadaptation between genotypes, for example, in mate choice.