The Hedgehog signalling pathway in bone formation.
The Hedgehog signalling pathway in bone formation.
复制标题
骨形成中的刺猬信号通路。
DOI：
10.1038/ijos.2015.14
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发表时间：
2015-06-26
影响因子：
14.9
通讯作者：
Yang YZ
中科院分区：
文献类型：
--
作者：
Yang J;Andre P;Ye L;Yang YZ
Hedgehog (Hh) 信号通路在发育、体内平衡和肿瘤发生中发挥着许多重要作用。 Hh 信号在骨形成中的关键功能在过去二十年已被确定。在这里，我们回顾了进化上保守的 Hh 信号传导机制，重点关注 Hh 信号传导通路在骨骼发育、体内平衡和疾病中的功能。在胚胎肢体发育的早期阶段，Sonic Hedgehog (Shh) 在形成肢芽的过程中充当主要的形态发生素。 Indian Hedgehog (Ihh) 在软骨内骨化中具有重要功能，并诱导软骨膜中的成骨细胞分化。 Hh 信号传导还涉及膜内骨化。 Hh 和 Wnt 信号传导之间的相互作用调节软骨发育、软骨内骨形成和滑膜关节形成。 Hh 在骨稳态中也发挥着重要作用，减少 Hh 信号传导可以防止与年龄相关的骨质流失。 Hh 信号调节的破坏会导致多种骨疾病，例如进行性骨异型增生。因此，了解 Hh 信号在骨发育、稳态和疾病中的信号机制和功能将为骨疾病的预防、诊断和治疗提供重要的见解。
The Hedgehog (Hh) signalling pathway plays many important roles in development, homeostasis and tumorigenesis. The critical function of Hh signalling in bone formation has been identified in the past two decades. Here, we review the evolutionarily conserved Hh signalling mechanisms with an emphasis on the functions of the Hh signalling pathway in bone development, homeostasis and diseases. In the early stages of embryonic limb development, Sonic Hedgehog (Shh) acts as a major morphogen in patterning the limb buds. Indian Hedgehog (Ihh) has an essential function in endochondral ossification and induces osteoblast differentiation in the perichondrium. Hh signalling is also involved intramembrane ossification. Interactions between Hh and Wnt signalling regulate cartilage development, endochondral bone formation and synovial joint formation. Hh also plays an important role in bone homeostasis, and reducing Hh signalling protects against age-related bone loss. Disruption of Hh signalling regulation leads to multiple bone diseases, such as progressive osseous heteroplasia. Therefore, understanding the signalling mechanisms and functions of Hh signalling in bone development, homeostasis and diseases will provide important insights into bone disease prevention, diagnoses and therapeutics.