Histological comparison of three apatitic bone substitutes with different carbonate contents in alveolar bone defects in a beagle mandible with simultaneous implant installation
Histological comparison of three apatitic bone substitutes with different carbonate contents in alveolar bone defects in a beagle mandible with simultaneous implant installation
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DOI：
10.1002/jbm.b.34492
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发表时间：
2019-10-17
影响因子：
3.4
通讯作者：
Miyamoto, Youji
中科院分区：
文献类型：
--
作者：
Mano, Takamitsu;Akita, Kazuya;Miyamoto, Youji
由于骨磷灰石是磷灰石结构中含有碳酸盐的碳酸盐磷灰石，因此碳酸盐含量可能是控制磷灰石骨替代物骨传导性的因素之一。本研究的目的是评估碳酸盐含量对磷灰石骨替代物骨传导性的影响，使用三种市售骨替代物重建比格犬下颌骨的牙槽骨缺损，同时安装牙种植体。本研究中使用的 NEOBONE、Bio-Oss 和 Cytrans 分别含有 0.1、5.5 和 12.0 质量%的碳酸盐。 NEOBONE、Bio-Oss 和 Cytrans 的比格犬下颌骨牙槽骨缺损上部新生骨量在术后 4 周时分别为 0.7、6.6 和 39.4%，在术后 12 周时分别为 4.7、39.5 和 75.2%。结果表明，Cytrans 的骨与种植体接触比最大。此外，在使用 Cytrans 的情况下，牙槽嵴的连续性得以恢复，而在使用 NEOBONE 和 Bio-Oss 时，牙槽嵴的连续性不足。 Cytrans 和 Bio-Oss 的磷灰石结构中碳酸盐含量相对较高，随着时间的推移会被再吸收。我们得出结论，碳酸盐含量是控制磷灰石骨替代物骨传导性的重要因素之一。
Since bone apatite is a carbonate apatite containing carbonate in an apatitic structure, carbonate content may be one of the factors governing the osteoconductivity of apatitic bone substitutes. The aim of this study was to evaluate the effects of carbonate content on the osteoconductivity of apatitic bone substitutes using three commercially available bone substitutes for the reconstruction of alveolar bone defects of a beagle mandible with simultaneous dental implant installation. NEOBONE, Bio-Oss, and Cytrans that contain 0.1, 5.5, and 12.0 mass% of carbonate, respectively, were used in this study. The amount of newly formed bone in the upper portion of the alveolar bone defect of the beagle's mandible was 0.7, 6.6, and 39.4% at 4 weeks after surgery and 4.7, 39.5, and 75.2% at 12 weeks after surgery for NEOBONE, Bio-Oss, and Cytrans, respectively. The results indicate that bone-to-implant contact ratio was the largest for Cytrans. Additionally, the continuity of the alveolar ridge was restored in the case of Cytrans, whereas the continuity of the alveolar ridge was not sufficient when using NEOBONE and Bio-Oss. Both Cytrans and Bio-Oss that have a relatively larger carbonate content in their apatitic structure was resorbed with time. We concluded that carbonate content is one of important factors governing the osteoconductivity of apatitic bone substitutes.