Evolutionary relationships among diverse bacteriophages and prophages: All the world's a phage
Evolutionary relationships among diverse bacteriophages and prophages: All the world's a phage
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DOI：
10.1073/pnas.96.5.2192
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发表时间：
1999-03-02
影响因子：
11.1
通讯作者：
Hatfull, GF
中科院分区：
文献类型：
--
作者：
Hendrix, RW;Smith, MCM;Hatfull, GF
我们报告的DNA和预测的蛋白质序列的相似性，这意味着同源性，基因的双链DNA（dsDNA）噬菌体和噬菌体跨越广泛的宿主细菌的系统发育范围。本文报道的序列匹配建立了大肠杆菌的类噬菌体、链霉菌的噬菌体phi C31、分枝杆菌的噬菌体、流感嗜血杆菌基因组中以前未被识别的隐蔽前噬菌体phi flu和结核分枝杆菌基因组中的两个小的前噬菌体样元件phi Rv1和phi Rv2之间的遗传联系，但并不总是直接的。结果表明，这些噬菌体基因，很可能是所有的dsDNA尾噬菌体，共享共同的祖先。我们提出了一个模型的遗传结构和动力学的全球噬菌体群体中，所有的dsDNA噬菌体基因组是镶嵌访问，通过水平交换，一个大的共同的基因库，但在访问的基因库是不均匀的所有噬菌体。
We report DNA and predicted protein sequence similarities, implying homology, among genes of double-stranded DNA (dsDNA) bacteriophages and prophages spanning a broad phylogenetic range of host bacteria. The sequence matches reported here establish genetic connections, not always direct, among the lambdoid phages of Escherichia coli, phage phi C31 of Streptomyces, phages of Mycobacterium, a previously unrecognized cryptic prophage, phi flu, in the Haemophilus influenzae genome, and two small prophage-like elements, phi Rv1 and phi Rv2, in the genome of Mycobacterium tuberculosis. The results imply that these phage genes, and very possibly all of the dsDNA tailed phages, share common ancestry. We propose a model for the genetic structure and dynamics of the global phage population in which all dsDNA phage genomes are mosaics with access, by horizontal exchange, to a large common genetic pool but in which access to the gene pool is not uniform for all phage.