Resistin expression in breast cancer tissue as a marker of prognosis and hormone therapy stratification
Resistin expression in breast cancer tissue as a marker of prognosis and hormone therapy stratification
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DOI：
10.1016/j.ygyno.2012.02.032
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发表时间：
2012-06-01
影响因子：
4.7
通讯作者：
Yuan, Shyng-Shiou F.
中科院分区：
文献类型：
--
作者：
Lee, Yi-Chen;Chen, Yun-Ju;Yuan, Shyng-Shiou F.
目标。脂肪细胞因子是脂肪细胞衍生的激素，有充分的证据表明它与致癌有关。检测新发现的脂肪细胞因子抵抗素在乳腺癌组织中的表达，并与患者临床病理变量进行相关性分析。免疫组化分析抵抗素在乳腺癌组织及正常乳腺旁组织中的表达，卡方检验与临床病理变量及复发率的相关性，Kaplan-Meier估计确定抵抗素对无病生存和总生存的预后价值，log-rank检验评价曲线间差异的显著性。抵抗素的高表达主要见于乳腺癌组织，而不见于邻近的正常乳腺组织。抵抗素在乳腺癌组织中的高表达与肿瘤分期、肿瘤大小、淋巴结转移及雌激素受体状态有显著相关性。在抵抗素高表达患者中，激素治疗而非放疗或化疗可降低复发率。虽然高抵抗素表达与较差的无病生存期和总生存期相关，但Cox回归分析也显示抵抗素是无病生存期和总生存期的独立预测因子。抵抗素在乳腺癌组织中的高表达与更恶性的临床病理状态以及较差的患者生存有关。因此，抵抗素可能有望作为乳腺癌的独立预后预测因子，作为激素治疗分层的标志，并作为潜在的治疗靶点。(C) 2012爱思唯尔公司版权所有。
Objective. Adipocytokines are adipocyte-derived hormones and well documented to be involved in carcinogenesis. The expression of resistin, a newly discovered adipocytokine, in breast cancer tissues was determined and correlated with patient clinicopathological variables.Methods. Resistin expression in breast cancer tissues and the normal adjacent breast tissues was analyzed by immunohistochemistry and was correlated with clinicopathological variables as well as recurrence rates by the chi-square test The prognostic value of resistin for disease-free and overall survival was determined by Kaplan-Meier estimates, and the significance of differences between curves was evaluated by the log-rank test.Results. High resistin expression was predominantly observed in breast cancer tissues but not the adjacent normal breast tissues. High resistin expression in breast cancer tissues was correlated significantly with tumor stage, tumor size, lymph node metastasis and estrogen receptor status. Hormone therapy, but not radiotherapy or chemotherapy, decreased the recurrence rate in patients with high resistin expression. While high resistin expression was associated with poor disease-free and overall survival, Cox regression analysis also revealed that resistin was an independent predictor of disease-free and overall survival.Conclusions. High resistin expression in breast cancer tissue is associated with a more malignant clinicopathological status as well as poor patient survival. Resistin may therefore hold promise as an independent prognosis predictor for breast cancer, as a marker for hormone therapy stratification and as a potential therapeutic target. (C) 2012 Elsevier Inc. All rights reserved.