Airway Bradykinin Receptors
Airway Bradykinin Receptors
复制标题
气道缓激肽受体
DOI：
10.1111/j.1749-6632.1991.tb37980.x
复制
发表时间：
1991
影响因子：
5.2
通讯作者：
R. Burch
中科院分区：
文献类型：
--
作者：
S. G. Farmer;R. Burch
缓激肽（BK，Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg）是一种在炎症反应中释放的九肽，是一种强效的平滑肌痉挛原，可刺激感觉神经末梢，引起血管舒张和微血管渗漏。此外，BK刺激炎症介质的释放，如血小板活化因子（PAF）、肽白三烯、白三烯B4、羟基四烯酸以及许多组织（包括气道组织）中的各种胰头素。此外，BK可以刺激感觉神经末梢释放速激肽，如P物质，导致气道中的神经源性炎症。BK作用于细胞表面受体释放的所有物质都与哮喘的发病机制有关。近年来，激肽如BK和Lys-BK（kallidin，KD）在炎症反应中的作用及其产生机制已被广泛综述。因此，有充分的证据表明这些肽有助于与过敏、关节炎、胰腺炎、病毒性鼻炎和炎性肠病的症状相关的炎症反应。11313-17在哮喘患者中，吸入BK是已知最有效的支气管收缩剂之一。过敏性哮喘患者在过敏原攻击后气道激肽水平增加。BK在动物和人类体内和体外气道中的许多作用，以及这种炎性肽在过敏性鼻炎和哮喘发病机制中的假定作用，最近也成为综述的主题。13~ 16，22-zJ本文将试图提供一个深入了解我们的知识的发展，在气道激肽受体的药理学。
Bradykinin (BK, Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg), a nonapeptide released during the inflammatory response, is a potent smooth muscle spasmogen, which stimulates sensory nerve endings, and causes vasodilation and microvascular leakage. In addition, BK stimulates the release of inflammatory mediators such as platelet-activating factor (PAF), peptidoleukotrienes, leukotriene B4, hydroxytetraenoic acids, as well as various prostaglandins in many tissues including those of the airways.'-7 Furthermore, BK can stimulate sensory nerve endings to release tachykinins such as substance P, contributing to neurogenic inflammation in the airways.% l0 All of the substances, released by BK acting on cell surface receptors, have been implicated in the pathogenesis of asthma. The roles of kinins such as BK and Lys-BK (kallidin, KD) in inflammation, and the events leading to their production have been extensively reviewed re-~ ently.~ I-~~ Thus, there is substantial evidence that these peptides contribute to the inflammatory response associated with symptoms of allergy, arthritis, pancreatitis, viral rhinitis and inflammatory bowel disease. 11313-17 In asthmatic patients, inhaled BK is one of the most potent bronchoconstrictor agents kno~ n,~~.~~ and airway kinin levels are increased in allergic asthmatics following allergen challenge. 20, 21 The many effects of BK in the airways in uivo and in vitro in animals and humans, as well as the putative roles of this inflammatory peptide in the pathogenesis of allergic rhinitis and asthma, have also recently been the subject of reviews. 13~ 16, 22-zJ The present article will attempt to provide an insight into developments in our knowledge of the pharmacology of kinin receptors in the airways.
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影响因子：
15.9
作者：
CHRISTIANSEN, SC;PROUD, D;COCHRANE, CG
通讯作者：
COCHRANE, CG
两个具有皮摩尔亲和力的缓激肽结合位点。
DOI：
--
发表时间：
1986
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Manning,DC;Vavrek,R;Stewart,JM;Snyder,SH
通讯作者：
Snyder,SH
缓激肽拮抗剂可阻断绵羊抗原诱导的气道高反应性和炎症。
DOI：
10.1016/0952-0600(90)90003-2
发表时间：
1990
期刊：
Pulmonary pharmacology
影响因子：
--
作者：
Solèr,M;Sielczak,M;Abraham,WM
通讯作者：
Abraham,WM
过敏绵羊过敏原诱导的早期和晚期气道反应和抗原诱导的气道高反应性的药理学。
DOI：
10.1016/s0952-0600(89)80007-9
发表时间：
1989
期刊：
Pulmonary pharmacology
影响因子：
--
作者：
Abraham,WM
通讯作者：
Abraham,WM
中性肽链内切酶和血管紧张素转换酶抑制剂可增强激肽诱导的雪貂气管收缩。
DOI：
--
发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Dusser,DJ;Nadel,JA;Sekizawa,K;Graf,PD;Borson,DB
通讯作者：
Borson,DB