Mycobacterial infection: A difficult and late diagnosis in stem cell transplant recipients
Mycobacterial infection: A difficult and late diagnosis in stem cell transplant recipients
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DOI：
10.1086/383307
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发表时间：
2004-05-01
影响因子：
11.8
通讯作者：
Rovira, M
中科院分区：
文献类型：
--
作者：
Cordonnier, C;Martino, R;Rovira, M
欧洲血液和骨髓移植组织的传染病工作组进行了一项调查，以获得有关干细胞移植(SCT)受者中分枝杆菌感染(MBI)的频率、表现和治疗的信息。在1994年至1998年期间的29个中心中，1513名异体移植受者中有0.79%的人被诊断为MBI，在3012名自体SCT受者中有0.23%的人被诊断为MBI，中位数为移植后160天。首次症状和诊断之间的平均间隔为29天，对于不典型的MBI患者或接受皮质类固醇治疗的患者来说，间隔时间更长。在接受匹配的、无关的或不匹配的来自相关捐赠者的STC的患者中，MBI的患病率最高。在31名患者中，20名患者患有结核病，8名患者患有不典型的MBI，3名患者仅根据组织学结果进行了诊断。5名患者(16%)死亡，他们都接受了同种异体SCT。由于结核病高发国家中不匹配的捐献者和移植计划的数量不断增加，需要持续保持警惕，以早期发现SCT接受者的MBI。
The Infectious Diseases Working Party of the European Blood and Marrow Transplant Group conducted a survey to obtain information about the frequency, presentation, and treatment of mycobacterial infection (MBI) in stem cell transplant (SCT) recipients. Among 29 centers, MBI was diagnosed in 0.79% of 1513 allogeneic and 0.23% of 3012 autologous SCT recipients during 1994 - 1998 a median of 160 days after transplantation. The mean interval between first symptoms and diagnosis was 29 days and was still longer for patients with atypical MBI or recipients of corticosteroid therapy. The prevalence of MBI was highest among those who received matched unrelated or mismatched STCs from related donors. Of 31 patients, 20 had tuberculosis, 8 had atypical MBI, and 3 had diagnoses based on histological findings only. Five patients (16%) died, all of whom had received an allogeneic SCT. Because of the increased numbers of unmatched donors and transplantation programs in countries with a high prevalence of tuberculosis, constant vigilance is required to early detect MBI in SCT recipients.