The role of connexin-mediated cell-cell communication in breast cancer metastasis
The role of connexin-mediated cell-cell communication in breast cancer metastasis
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DOI：
10.1023/a:1014787014851
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发表时间：
2001-10-01
影响因子：
2.5
通讯作者：
Batist, G
中科院分区：
文献类型：
--
作者：
Carystinos, GD;Bier, A;Batist, G
缝隙连接细胞间通讯(GJIC)是细胞间通讯的一种形式，介导相邻细胞之间的小分子交换。缝隙连接(GJS)是由连接蛋白(CXS)形成的，受到严格的动态调控。它们参与细胞周期、分化和细胞信号传递。CXS和GJS的缺失是癌变的标志，而它们在癌细胞中的诱导导致癌症表型逆转、诱导分化和调节细胞生长。在对乳腺癌中CX缺失的观察的基础上，本文就CXS在乳腺癌转移中的作用作一综述。以往的研究表明，Cx的表达与转移潜能呈负相关。这可能是由于相邻细胞之间失去合作，导致肿瘤内细胞异质性和细胞解离所致。我们将讨论Cx活性在肿瘤转移过程中的可能参与。
Gap junctional intercellular communication (GJIC) is a form of cell-cell communication mediating the exchange of small molecules between neighboring cells. Gap junctions (GJs) are formed by connexins (Cxs), and are subject to tight and dynamic regulation. They are involved in the cell cycle, differentiation, and cell signaling. The loss of Cxs and GJs is a hallmark of carcinogenesis, while their induction in cancer cells leads to a reversal of the cancer phenotype, induction of differentiation, and regulation of cell growth. On the basis of the observations about Cx loss in breast cancer, this review examines Cxs' involvement in breast cancer metastasis. Previous work indicates that Cx expression is inversely correlated to metastatic potential. This is probably because of the loss of cooperation between neighboring cells, leading to cell heterogeneity and cell dissociation in the tumor. The possible involvement of Cx activity during metastasis will be discussed.