Odor identification in normal aging and early Alzheimer's disease:: Effects of retrieval support
Odor identification in normal aging and early Alzheimer's disease:: Effects of retrieval support
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DOI：
10.1037/0894-4105.13.1.47
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发表时间：
1999-01-01
期刊：
影响因子：
2.4
通讯作者：
Bäckman, L
中科院分区：
文献类型：
--
作者：
Larsson, M;Semb, H;Bäckman, L
在正常衰老和早期阿尔茨海默病（AD）中检查了气味敏感性和识别能力。目的是调查 AD 与较低气味敏感性的关系、作为检索支持功能的气味识别以及整体认知功能（简易精神状态检查 [MMSE]；M. F. Folstein、S. E. Folstein 和 P. R. McHugh，1975）与嗅觉表现之间的关系。结果表明 AD 的气味敏感性完整，但气味识别不足。两组患者都从识别线索中受益，并且 AD 患者和对照组的获益程度同样大。 AD 患者的检索支持没有选择性获益的发现表明，嗅觉知识的退化导致了这些患者的气味识别缺陷。 MMSE 与识别呈正相关，而 MMSE 与嗅觉敏感性不相关。这些发现表明，AD 相关的嗅觉障碍源于皮质而非周围结构的病变。
Odor sensitivity and identification were examined in normal aging and early Alzheimer's disease (AD). The aims were to investigate AD as associated with lower odor sensitivity, odor identification as a function of retrieval support, and the relationship between global cognitive functioning (Mini-Mental State Exam [MMSE]; M. F. Folstein, S. E. Folstein, & P. R. McHugh, 1975) and olfactory performance. Results indicated intact odor sensitivity but deficient odor identification in AD. Both groups benefited from cues in identification, and the size of the gains was equally large in AD patients and controls. The finding of no selective benefit from retrieval support in AD suggests that a degradation of olfactory knowledge contributes to the odor identification deficits in these patients. MMSE and identification were positively related, whereas MMSE and olfactory sensitivity were unrelated. These findings suggest that the AD-related olfactory impairment stems from lesions in cortical rather than peripheral structures.