RESPONSES OF SMOOTH MUSCLES TO QUICK STRETCH - RELATION OF STRETCH TO CONDUCTION
RESPONSES OF SMOOTH MUSCLES TO QUICK STRETCH - RELATION OF STRETCH TO CONDUCTION
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DOI：
10.1152/ajplegacy.1960.198.5.921
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发表时间：
1960-01-01
影响因子：
--
通讯作者：
PROSSER, CL
中科院分区：
文献类型：
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作者：
BURNSTOCK, G;PROSSER, CL
对孤立的内脏肌肉条进行快速拉伸会引起收缩和电反应；类似的拉伸不会引起血管和瞬膜的反应。高度兴奋的肌肉会产生重复的反应。自发活跃的大肠杆菌因拉伸而放松，电活动也相应减弱。膜电位（蔗糖间隙测量）在拉伸过程中降低；尖峰出现在去极化的临界水平。有时在膜去极化之前会出现单个初始尖峰。自发活动肌肉的膜电位在拉伸过程中增加。机械固定在中心的平滑肌条显示从一侧到另一侧的传导；发出激活和放松的信号。结论是，传导可以在没有拉伸的情况下发生，快速拉伸可以改变膜电位，从而改变平滑肌的兴奋性。
Quick stretches applied to isolated strips of visceral muscles elicit contractions and electrical responses; similar stretches elicit no responses from blood vessels and nictitating membrane. Highly excitable muscles gave repetitive responses. Spontaneously active taenia coli relaxed in response to stretch and electrical activity diminished correspondingly. The membrane potential (sucrose gap measurement) decreased during stretch; spikes appeared at a critical level of depolarization. A single initial spike sometimes occurred before membrane depolarization. The membrane potential of spontaneously active muscle increased during stretch. Strips of smooth muscle mechanically immobilized in the center showed conduction from one side to the other; signals for both activation and relaxation were conducted. It is concluded that conduction can occur in absence of stretch, that quick stretch can alter membrane potential and thus alter excitability of smooth muscle.