Bone marrow with diffuse tumor infiltration in patients with lymphoproliferative diseases: Dynamic gadolinium-enhanced MR imaging
Bone marrow with diffuse tumor infiltration in patients with lymphoproliferative diseases: Dynamic gadolinium-enhanced MR imaging
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DOI：
10.1148/radiol.2293020748
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发表时间：
2003-12-01
期刊：
影响因子：
19.7
通讯作者：
Kobeiter, H
中科院分区：
文献类型：
--
作者：
Rahmouni, A;Montazel, JL;Kobeiter, H
目得：评价淋巴组织增生性疾病和弥漫性骨髓受累患者的骨髓钆增强。材料和方法：对42例经组织学证实的弥漫性骨髓受累和新诊断的骨髓瘤（n = 31），非霍奇金淋巴瘤（n = 8），或霍奇金病（n = 3）。根据增强时间曲线（ETC）确定最大增强百分比（E-max）、增强斜率和增强洗脱。根据骨髓样本中肿瘤细胞的百分比，对骨髓受累进行三级评分。42例患者的定量ETC值与健康受试者的ETC值进行了比较，并通过平均值t检验比较骨髓受累的等级。受试者工作特征（ROC）分析进行比较E-max值之间的患者和那些没有骨髓受累。9例患者的基线和随访MR成像结果进行了比较。
PURPOSE: To evaluate gadolinium enhancement of bone marrow in patients with lymphoproliferative diseases and diffuse bone marrow involvement.MATERIALS AND METHODS: Dynamic contrast material-enhanced magnetic resonance (MR) imaging of the thoracolumbar spine was performed in 42 patients with histologically proved diffuse bone marrow involvement and newly diagnosed myeloma (n = 31), non-Hodgkin lymphoma (n = 8), or Hodgkin disease (n = 3). The maximum percentage of enhancement (E-max), enhancement slope, and enhancement washout were determined from enhancement time curves (ETCs). A three-grade system for scoring bone marrow involvement was based on the percentage of neoplastic cells in bone marrow samples. Quantitative ETC values for the 42 patients were compared with ETC values for healthy subjects and with grades of bone marrow involvement by using mean t test comparisons. Receiver operating characteristic (ROC) analysis was conducted by comparing E-max values between patients with and those without bone marrow involvement. Baseline and follow-up MR imaging findings were compared in nine patients.RESULTS: Significant differences in E-max (P