[Elevated concentration of serum carcinoembryonic antigen in hypothyroidism].
[Elevated concentration of serum carcinoembryonic antigen in hypothyroidism].
复制标题
甲状腺功能减退症血清癌胚抗原浓度升高。
DOI：
--
复制
发表时间：
2004
影响因子：
--
通讯作者：
S. Bonizzato
中科院分区：
文献类型：
--
作者：
G. Bertola;G. Balza;A. Oriani;D. Morganti;C. Sironi;S. Bonizzato
在这个病例报告中，我们描述了两个甲状腺功能减退症和癌胚抗原（CEA）血清浓度升高的患者。前一个病人是一名妇女受原发性自身免疫性甲状腺功能减退症，后者继发性甲状腺功能减退症的空蝶鞍综合征。在这两名患者中，我们发现没有证据表明肿瘤性疾病和CEA血清浓度几乎完全恢复到正常范围值后，患者给予激素替代治疗与L-甲状腺素。虽然甲状腺功能减退症与CEA血清浓度升高的相关性已在文献中报道，但当医生面对CEA水平升高的患者时，甲状腺功能减退症通常被忽视。相反，我们的数据表明，甲状腺功能减退症应考虑到这些患者的诊断工作，如吸烟，胆汁淤积，肝功能受损，慢性炎症性支气管和肠道疾病。
In this case-report we describe two patients with hypothyroidism and increased carcinoembryonic antigen (CEA) serum concentration. The former patient was a woman affected by primary autoimmune hypothyroidism, the latter by secondary hypothyroidism in empty sella syndrome. In both of the patients we found no evidence of neoplastic disease and CEA serum concentrations reverted almost completely to the normal range values after the patients were given the hormonal replacement therapy with L-thyroxine. Although the association of hypothyroidism with elevated CEA serum concentrations has been already reported in the literature, hypothyroidism is usually disregarded when a physician is facing with a patient with increased CEA levels. On the contrary, our data suggest that hypothyroidism should be taken into account in the diagnostic work-up of these patients, such as smoking, cholestasis, impaired liver function, chronic inflammatory bronchial and bowel disease.