Quantitative and qualitative impairments in skilled reaching in the mouse (Mus musculus) after a focal motor cortex stroke
Quantitative and qualitative impairments in skilled reaching in the mouse (Mus musculus) after a focal motor cortex stroke
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DOI：
10.1161/01.str.0000020714.48349.4e
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发表时间：
2002-07-01
期刊：
影响因子：
8.3
通讯作者：
Whishaw, IQ
中科院分区：
文献类型：
--
作者：
Farr, TD;Whishaw, IQ
背景和目的：熟练的伸手动作是人类运动行为的一个重要方面，但在运动系统卒中后受损。本研究的目的是记录熟练的运动在小鼠之前和之后的一个局灶性运动皮层中风的目的，开发一个小鼠模型的人类stroke.Methods-Male C57/BL 6小鼠训练达到与前肢的食物颗粒，然后给予运动皮层中风，诱导软脑膜剥离，对侧到他们的首选达到肢体。达到成功和达到所使用的运动进行了分析，通过逐帧检查术前和术后的视频records.Results-Reaching成功中风后严重受损。术后2周内的成功改善为中度。10个运动组件，包括达到手术前和手术后的分析表明，用于瞄准，推进，旋前，旋后的爪子肢体的旋转运动大部分受损。当成功达到确实发生，身体运动，补偿肢体旋转运动的损伤assistedthem. Conclusions的结果表明，熟练达到在小鼠受损的局灶性运动皮层中风，他们建议，小鼠，和熟练的达到任务，提供了一个很好的模型，用于研究运动系统中风后的损伤，补偿和恢复。
Background and Purpose-Skilled reaching movements are an important aspect of human motor behavior but are impaired after motor system stroke. The, purpose of this study was to document skilled movements in mice before and after a focal motor cortex stroke for the purpose of developing a mouse model of human stroke.Methods-Male C57/BL6 mice were trained to reach with a forelimb for food pellets and then given a motor cortex stroke, induced by pial stripping, contralateral to their preferred reaching limb. Reaching success and the movements used in reaching were analyzed by frame-by-frame inspection of presurgical and postsurgical video records.Results-Reaching success was severely impaired after the stroke. Improvement in success over 2 postsurgical weeks was moderate. Analysis of 10 movement components comprising reaches pre- and postsurgically indicated that most of the rotatory movements of the limb used for aiming, advancing, pronating, and supinating the paw were impaired. When successful reaches did occur, body movements that compensated for the impairments in limb rotatory movements aided them.Conclusions-The results indicate that skilled reaching in the mouse is impaired by focal motor cortex stroke and they suggest that the mouse, and the skilled reaching task, provides an excellent model for studying impairments, compensation, and recovery after motor system stroke.