PREVENTION OF EXERCISE-INDUCED MUSCLE MEMBRANE DAMAGE BY ESTRADIOL
PREVENTION OF EXERCISE-INDUCED MUSCLE MEMBRANE DAMAGE BY ESTRADIOL
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DOI：
10.1016/0024-3205(88)90243-3
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
BLANKENSTEIN, MA
中科院分区：
文献类型：
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作者：
BAR, PR;AMELINK, GJ;BLANKENSTEIN, MA
运动会破坏肌肉膜，随后某些肌肉蛋白质会泄漏到血液中。这种运动后的反应对男性和女性是不同的；作为对这种差异的解释，有人认为雌激素对女性肌膜具有保护作用。我们最近开发了一种动物运动模型，在这种模型中，运动后的损伤可以在实验动物体内进行研究。运动后的二形性，类似于人类，在大鼠中存在，并发现了雌激素(E_2)参与的间接证据。我们在这里报道：1)去卵巢的女性和男性一样表现出运动后的损伤，2)这种反应可以通过运动前补充E2来预防，3)经过E2治疗后，男性不再表现出运动后的肌肉损伤。因此，我们得出结论，雌二醇确实在保护骨骼肌方面发挥着重要作用，无论是对女性还是男性。
Exercise can damage the muscle membrane, followed by leakage of certain muscle proteins into the bloodstream. This postexercise response differs for males and females; as an explanation for this difference it has been suggested that oestrogens have a protective effect on the female muscle membrane. We recently developed an animal exercise model in which postexercise damage can be studied in laboratory animals in vivo. A postexercise dimorphism, similar to that in humans, exists in rats and indirect evidence for the involvement of oestradiol (E2) was found. We report here 1) that ovariectomized females show postexercise damage like males, 2) that this response can be prevented by E2-replacement before exercise, and 3) that males, after E2-treatment, no longer show postexercise muscle damage. We therefore conclude that oestradiol indeed plays an important role in protecting skeletal muscle, both in females and in males.