Decreased salivary immunoglobulin A secretion rate after intense interval exercise in elite kayakers
Decreased salivary immunoglobulin A secretion rate after intense interval exercise in elite kayakers
复制标题
精英皮划艇运动员剧烈间歇运动后唾液免疫球蛋白 A 分泌率降低
DOI：
10.1007/bf00376664
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
G. Seymour
中科院分区：
文献类型：
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作者：
Laurel Traeger Mackinnon;E. Ginn;G. Seymour
摘要耐力运动员在高强度训练和比赛后上呼吸道感染（URTI;如感冒、咽喉痛）的发病率很高。先前的研究表明，分泌型免疫球蛋白A（伊加）的浓度，宿主防御微生物引起URTI的主要效应，在激烈的耐力运动后下降。许多运动员进行激烈的间歇运动作为他们正常训练的一部分。本研究的目的是确定是否唾液伊加浓度也降低后，激烈的间歇运动在正常的训练制度在优秀运动员。在为期3周的3次水上训练之前和之后，从8名优秀男性皮艇运动员中获得定时唾液样本。用酶联免疫吸附试验分别测定伊加、IgG和IgM的浓度，并计算每种IG的分泌率。在所有三次训练后，伊加分泌率（μg·min-1）下降了27%-38%（P=0.007）;最大的下降幅度（38%）出现在一周特别密集训练结束时的最密集训练后。与其他2天相比，该训练日的伊加相对于总蛋白的浓度（μg·mg蛋白-1）显著降低（P<0.05）。IgG和IgM的浓度和分泌率在运动后没有变化，表明对伊加有特异性影响。这些数据表明，在优秀运动员中，伊加浓度和分泌率降低了激烈的间歇运动，运动引起的伊加输出的变化可能是一种机制，有助于URTI在优秀运动员。
SummaryEndurance athletes have been shown to suffer a high incidence of upper respiratory tract infection (URTI; e.g. colds, sore throat) during intense training and after competition. Previous studies have shown that concentrations of secretory immunoglobulin A (IgA), the major effector of host defense against micro-organisms causing URTI, decrease after intense endurance exercise. Many athletes perform intense interval exercise as part of their normal training. The purpose of this study was to determine whether salivary IgA concentrations also decrease after intense interval exercise during the normal training regime in elite athletes. Timed saliva samples were obtained from eight elite male kayakers immediately before and after three on-water training sessions during a 3-week period. The concentrations of IgA, IgG and IgM were determined separately by enzyme-linked immunosorbent assay, and secretion rates calculated for each Ig. The IgA secretion rate (μg·min−1) decreased 27%–38% after all three training sessions (P=0.007); the largest decrease (38%) was noted after the most intense session at the end of an especially intense week of training. The IgA concentration relative to total protein (μg·mg protein−1) was significantly lower (P<0.05) on this training day compared with the other 2 days. Concentrations and secretion rates of IgG and IgM did not change after exercise, indicating a specific effect on IgA. These data would suggest that, in elite athletes, IgA concentration and secretion rate are reduced by intense interval exercise, and that exercise-induced changes in IgA output may be be one mechanism contributing to URTI in elite athletes.