Methicillin-resistant Staphylococcus aureus as a causative agent of postoperative intra-abdominal infection:: Relation to nasal colonization
Methicillin-resistant Staphylococcus aureus as a causative agent of postoperative intra-abdominal infection:: Relation to nasal colonization
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DOI：
10.1086/313454
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发表时间：
1999-11-01
影响因子：
11.8
通讯作者：
Desmonts, JM
中科院分区：
文献类型：
--
作者：
Fierobe, L;Decré, D;Desmonts, JM
在一所大学医院的外科重症监护室，我们调查了术后腹腔内感染（pIAI）期间获得耐甲氧西林金黄色葡萄球菌（MRSA）的频率和危险因素。我们对73例pIAI患者进行了为期17个月的前瞻性MRSA鼻腔筛查和病例评价。当从腹膜内液培养获得MRSA时，诊断MRSA pIAI。通过基因组分析评估鼻腔和腹膜MRSA菌株的身份。12名患者患有MRSA pIAI，占73名患者所有MRSA感染的21%。器官系统衰竭评分大于或等于1和pIAI前MRSA鼻携带是获得MRSA pIAI的独立危险因素，MRSA pIAI患者比无MRSA pIAI的患者有更长的重症监护病房住院时间和更多的再次手术。我们得出结论，MRSA可能是一个致病病原体在pIAI，并可能与鼻腔定植。
In the surgical intensive care unit of a university hospital, we investigated the frequency of and the risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) during postoperative intra-abdominal infection (pIAI). We conducted a prospective MRSA nasal screening and case evaluation for 17 months among 73 consecutive patients with having pIAI. MRSA pIAI was diagnosed when MRSA was obtained from culture of intraperitoneal fluids. The identity of nasal and peritoneal MRSA strains was assessed by genomic analysis. Twelve patients had MRSA pIAI, representing 21% of all MRSA infections acquired by the 73 patients. An organ system failure score of greater than or equal to 1 and MRSA nasal carriage prior to pIAI were the independent risk factors for acquisition of MRSA pIAI, Patients with MRSA pIAI had a longer intensive care unit stay and more reoperations than did those free of MRSA pIAI. We conclude that MRSA may be a causative pathogen in pIAI and may be related to nasal colonization.