Pathophysiology of tension-type headache.
Pathophysiology of tension-type headache.
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DOI：
10.1007/s11916-005-0021-8
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发表时间：
2005-12-01
影响因子：
3.7
通讯作者：
Ashina, Messoud
中科院分区：
文献类型：
--
作者：
Ashina, Sait;Bendtsen, Lars;Ashina, Messoud
紧张性头痛是最常见的原发性头痛疾病之一。基础疼痛和临床研究的进展提高了我们对紧张性头痛病理生理机制的认识。反复和持续的颅周围肌筋膜输入引起的中枢神经系统兴奋性增加可能是阵发性紧张性头痛转变为慢性头痛的原因。一氧化氮（NO）机制的研究表明，NO可能在紧张性头痛的病理生理中发挥关键作用，一氧化氮合酶抑制剂的抗痛觉作用可能成为未来治疗慢性头痛的新原理。未来的研究应侧重于外周伤害感觉的来源、下行疼痛调节的作用以及紧张性头痛动物模型的建立，以支持中枢致敏在紧张性头痛中的病理生理学重要性。
Tension-type headache is one of the most common primary headache disorders. Advances in basic pain and clinical research have improved our understanding of pathophysiologic mechanisms of tension-type headache. Increased excitability of the central nervous system generated by repetitive and sustained pericranial myofascial input may be responsible for the transformation of episodic tension-type headache into the chronic form. Studies of nitric oxide (NO) mechanisms suggest that NO may play a key role in the pathophysiology of tension-type headache and that the antinociceptive effect of nitric oxide synthase inhibitors may become a novel principle in the future treatment of chronic headache. Future studies should focus on investigation of the source of peripheral nociception, the role of descending pain modulation, and the development of an animal model of tension-type headache to support the pathophysiologic importance of central sensitization in tension-type headache.