Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy
Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy
复制标题
肿瘤胞吐外泌体/聚集诱导发射发光原混合纳米囊泡促进有效的肿瘤渗透和光动力治疗
DOI：
10.1002/anie.202003672
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发表时间：
2020
影响因子：
16.6
通讯作者：
Tang Ben Zhong
中科院分区：
文献类型：
--
作者：
Zhu Daoming;Duo Yanhong;Suo Meng;Zhao Yonghua;Xia Ligang;Zheng Zheng;Li Yang;Tang Ben Zhong
具有聚集诱导发射（AIE）特性的新型光敏剂的开发推动了光动力疗法（PDT）领域的重大进展。采用电穿孔方法制备肿瘤胞吐外泌体/AIE发光原（AIEgen）混合纳米囊泡（DES），可促进有效的肿瘤渗透。然后使用地塞米松使肿瘤微环境（TME）内的血管功能正常化，以减少局部缺氧，从而显着增强DES纳米囊泡的PDT功效，使其能够有效抑制肿瘤生长。首次实现了AIEgen与生物肿瘤胞吐外泌体的杂交，并与PDT方法相结合，通过使肿瘤内脉管系统正常化作为减少局部组织缺氧的手段。这项工作突出了基于 AIEgen 的 PDT 系统设计的新方法，并强调了 AIEgens 的潜在临床价值。
The development of novel photosensitizing agents with aggregation-induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor-exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor-exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen-based PDT systems and underscores the potential clinical value of AIEgens.